Developing a Mathematical Model of Intracellular Calcium Dynamics for Evaluating Combined Anticancer Effects of Afatinib and RP4010 in Esophageal Cancer

Targeting dysregulated Ca(2+) signaling in cancer cells is an emerging chemotherapy approach. We previously reported that store-operated Ca(2+) entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. As a tyrosine kinase inhibitor (TKI), afatinib received FDA appr...

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Detalles Bibliográficos
Autores principales: Chang, Yan, Funk, Marah, Roy, Souvik, Stephenson, Elizabeth, Choi, Sangyong, Kojouharov, Hristo V., Chen, Benito, Pan, Zui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836083/
https://www.ncbi.nlm.nih.gov/pubmed/35163685
http://dx.doi.org/10.3390/ijms23031763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836083/
https://www.ncbi.nlm.nih.gov/pubmed/35163685
http://dx.doi.org/10.3390/ijms23031763

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