Cargando…

Developing a Mathematical Model of Intracellular Calcium Dynamics for Evaluating Combined Anticancer Effects of Afatinib and RP4010 in Esophageal Cancer

Targeting dysregulated Ca(2+) signaling in cancer cells is an emerging chemotherapy approach. We previously reported that store-operated Ca(2+) entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. As a tyrosine kinase inhibitor (TKI), afatinib received FDA appr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Yan, Funk, Marah, Roy, Souvik, Stephenson, Elizabeth, Choi, Sangyong, Kojouharov, Hristo V., Chen, Benito, Pan, Zui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836083/ https://www.ncbi.nlm.nih.gov/pubmed/35163685 http://dx.doi.org/10.3390/ijms23031763

Ejemplares similares

Compact quadrupole (MPS 4010-000-0)
por: Szeless, B
Publicado: (1973)

Tolerability of NGX-4010, a capsaicin 8% patch for peripheral neuropathic pain
por: Peppin, John F, et al.
Publicado: (2011)

TG4010: A therapeutic vaccine against MUC1 expressing tumors
por: Limacher, Jean-Marc, et al.
Publicado: (2012)

Viral based vaccine TG4010 induces broadening of specific immune response and improves outcome in advanced NSCLC
por: Tosch, Caroline, et al.
Publicado: (2017)

A mathematical model for the effects of amyloid beta on intracellular calcium
por: Latulippe, Joe, et al.
Publicado: (2018)

Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers
por: Chang, Yan, et al.
Publicado: (2021)

Identification of a Putative Enhancer RNA for EGFR in Hyper-Accessible Regions in Esophageal Squamous Cell Carcinoma Cells by Analysis of Chromatin Accessibility Landscapes
por: Choi, Sangyong, et al.
Publicado: (2021)

Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain
por: Webster, Lynn R, et al.
Publicado: (2012)

The complete genome sequence of the thermophilic bacterium Laceyella sacchari FBKL4.010 reveals the basis for tetramethylpyrazine biosynthesis in Moutai‐flavor Daqu
por: Li, Dounan, et al.
Publicado: (2019)

Appropriate Sequence for Afatinib and Cisplatin Combination Improves Anticancer Activity in Head and Neck Squamous Cell Carcinoma
por: Longton, Eleonore, et al.
Publicado: (2018)

Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
por: Zhang, Li, et al.
Publicado: (2023)

Clinical Pharmacokinetics and Pharmacodynamics of Afatinib
por: Wind, Sven, et al.
Publicado: (2016)

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases
por: Choi, Sangyong, et al.
Publicado: (2018)

TG4010 immunotherapy combined with first-line therapy in advanced non-small cell lung cancer (NSCLC): phase IIb results of the TIME study
por: Quoix, Elisabeth, et al.
Publicado: (2014)

Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia
por: Webster, Lynn R, et al.
Publicado: (2010)

Impact of TG4010 Vaccine on Health-Related Quality of Life in Advanced Non-Small-Cell Lung Cancer: Results of a Phase IIB Clinical Trial
por: Rotonda, Christine, et al.
Publicado: (2015)

TG4010 immunotherapy plus chemotherapy as first-line treatment of advanced non small cell lung cancer (NSCLC): Phase IIb results of the TIME trial
por: Nemunaitis, John, et al.
Publicado: (2015)

“Liquid elbows” due to afatinib administration
por: Zarogoulidis, Paul, et al.
Publicado: (2017)

Elevated Orai1 expression mediates tumor-promoting intracellular Ca(2+) oscillations in human esophageal squamous cell carcinoma
por: Zhu, Hua, et al.
Publicado: (2014)

Tolerability of NGX-4010, a capsaicin 8% dermal patch, following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with post-herpetic neuralgia
por: Webster, Lynn R, et al.
Publicado: (2011)

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials
por: Brown, Stephen, et al.
Publicado: (2013)

A New Improved RP-HPLC Method for Assay of Rosuvastatin Calcium in Tablets
por: Kaila, H. O., et al.
Publicado: (2010)

Mathematical modeling of intracellular signaling pathways
por: Klipp, Edda, et al.
Publicado: (2006)

Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte
por: Minicucci, Joseph, et al.
Publicado: (2021)

Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides
por: Hong, Shu-Ting, et al.
Publicado: (2019)

Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
por: Zhang, Xiaoli, et al.
Publicado: (2020)

Afatinib in Non–Small Cell Lung Cancer
por: Wirth, Scott M.
Publicado: (2015)

Chinese Medicine Treatment for Afatinib-Induced Paronychia
por: Yang, Pei-Yuu, et al.
Publicado: (2017)

Afatinib use in recurrent epithelial ovarian carcinoma
por: Shepherd-Littlejohn, Amanda L., et al.
Publicado: (2019)

Introduction of Plasmid to the Murine Gut via Consumption of an Escherichia coli Carrier and Examining the Impact of Bacterial Dosing and Antibiotics on Persistence
por: Kydd, LeNaiya, et al.
Publicado: (2022)

Stability Indicating RP-HPLC Estimation of Atorvastatin Calcium and Amlodipine Besylate in Pharmaceutical Formulations
por: Shah, D. A., et al.
Publicado: (2008)

RP considerations
por: Infantino, Angelo
Publicado: (2019)

RP rewind
Publicado: (2020)

Observational Study of Sequential Afatinib and Osimertinib in EGFR Mutation-Positive NSCLC: Patients Treated with a 40-mg Starting Dose of Afatinib
por: Yamamoto, Nobuyuki, et al.
Publicado: (2019)

Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
por: Inoue, Takako, et al.
Publicado: (2017)

Pharmacokinetics of afatinib in subjects with mild or moderate hepatic impairment
por: Schnell, David, et al.
Publicado: (2014)

Afatinib in advanced NSCLC: a profile of its use
por: Deeks, Emma D., et al.
Publicado: (2018)

First reported case of afatinib‐associated toxic megacolon
por: Kwok, Wang Chun, et al.
Publicado: (2018)

Mechanisms of acquired resistance to afatinib clarified with liquid biopsy
por: Nakamura, Tomomi, et al.
Publicado: (2018)

Efficacy and Safety Results of the Afatinib Expanded Access Program
por: Kim, Edward S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4bpnbnr27ckp39ddbe5s42pn2l