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Exploring the Structural Rearrangements of the Human Insulin-Degrading Enzyme through Molecular Dynamics Simulations

Insulin-degrading enzyme (IDE) is a ubiquitously expressed metallopeptidase that degrades insulin and a large panel of amyloidogenic peptides. IDE is thought to be a potential therapeutic target for type-2 diabetes and neurodegenerative diseases, such as Alzheimer’s disease. IDE catalytic chamber, k...

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Detalles Bibliográficos
Autores principales:	Ghoula, Mariem, Janel, Nathalie, Camproux, Anne-Claude, Moroy, Gautier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836115/ https://www.ncbi.nlm.nih.gov/pubmed/35163673 http://dx.doi.org/10.3390/ijms23031746

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