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Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins

Atopic dermatitis (AD) is a common T-helper 2 (Th2) lymphocyte-mediated chronic inflammatory skin disease characterized by disturbed epidermal differentiation (e.g., filaggrin (FLG) expression) and diminished skin barrier function. Therapeutics targeting the aryl hydrocarbon receptor (AHR), such as...

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Detalles Bibliográficos
Autores principales:	Rikken, Gijs, van den Brink, Noa J. M., van Vlijmen-Willems, Ivonne M. J. J., van Erp, Piet E. J., Pettersson, Lars, Smits, Jos P. H., van den Bogaard, Ellen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836151/ https://www.ncbi.nlm.nih.gov/pubmed/35163694 http://dx.doi.org/10.3390/ijms23031773

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