Cargando…

Role of the mtDNA Mutations and Mitophagy in Inflammaging

Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Dabravolski, Siarhei A., Nikiforov, Nikita G., Zhuravlev, Alexander D., Orekhov, Nikolay A., Grechko, Andrey V., Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836173/
https://www.ncbi.nlm.nih.gov/pubmed/35163247
http://dx.doi.org/10.3390/ijms23031323
_version_ 1784649612144934912
author Dabravolski, Siarhei A.
Nikiforov, Nikita G.
Zhuravlev, Alexander D.
Orekhov, Nikolay A.
Grechko, Andrey V.
Orekhov, Alexander N.
author_facet Dabravolski, Siarhei A.
Nikiforov, Nikita G.
Zhuravlev, Alexander D.
Orekhov, Nikolay A.
Grechko, Andrey V.
Orekhov, Alexander N.
author_sort Dabravolski, Siarhei A.
collection PubMed
description Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, is also discussed.
format Online
Article
Text
id pubmed-8836173
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88361732022-02-12 Role of the mtDNA Mutations and Mitophagy in Inflammaging Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Grechko, Andrey V. Orekhov, Alexander N. Int J Mol Sci Review Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, is also discussed. MDPI 2022-01-25 /pmc/articles/PMC8836173/ /pubmed/35163247 http://dx.doi.org/10.3390/ijms23031323 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dabravolski, Siarhei A.
Nikiforov, Nikita G.
Zhuravlev, Alexander D.
Orekhov, Nikolay A.
Grechko, Andrey V.
Orekhov, Alexander N.
Role of the mtDNA Mutations and Mitophagy in Inflammaging
title Role of the mtDNA Mutations and Mitophagy in Inflammaging
title_full Role of the mtDNA Mutations and Mitophagy in Inflammaging
title_fullStr Role of the mtDNA Mutations and Mitophagy in Inflammaging
title_full_unstemmed Role of the mtDNA Mutations and Mitophagy in Inflammaging
title_short Role of the mtDNA Mutations and Mitophagy in Inflammaging
title_sort role of the mtdna mutations and mitophagy in inflammaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836173/
https://www.ncbi.nlm.nih.gov/pubmed/35163247
http://dx.doi.org/10.3390/ijms23031323
work_keys_str_mv AT dabravolskisiarheia roleofthemtdnamutationsandmitophagyininflammaging
AT nikiforovnikitag roleofthemtdnamutationsandmitophagyininflammaging
AT zhuravlevalexanderd roleofthemtdnamutationsandmitophagyininflammaging
AT orekhovnikolaya roleofthemtdnamutationsandmitophagyininflammaging
AT grechkoandreyv roleofthemtdnamutationsandmitophagyininflammaging
AT orekhovalexandern roleofthemtdnamutationsandmitophagyininflammaging