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Role of the mtDNA Mutations and Mitophagy in Inflammaging
Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connecti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836173/ https://www.ncbi.nlm.nih.gov/pubmed/35163247 http://dx.doi.org/10.3390/ijms23031323 |
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author | Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Grechko, Andrey V. Orekhov, Alexander N. |
author_facet | Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Grechko, Andrey V. Orekhov, Alexander N. |
author_sort | Dabravolski, Siarhei A. |
collection | PubMed |
description | Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, is also discussed. |
format | Online Article Text |
id | pubmed-8836173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88361732022-02-12 Role of the mtDNA Mutations and Mitophagy in Inflammaging Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Grechko, Andrey V. Orekhov, Alexander N. Int J Mol Sci Review Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in physiological functionality and increasing vulnerability of the organism to environmental factors and pathogens, ending, eventually, in death. One of the most elaborated ageing theories implies a direct connection between ROS-mediated mtDNA damage and mutations. In this review, we focus on the role of mitochondrial metabolism, mitochondria generated ROS, mitochondrial dynamics and mitophagy in normal ageing and pathological conditions, such as inflammation. Also, a chronic form of inflammation, which could change the long-term status of the immune system in an age-dependent way, is discussed. Finally, the role of inflammaging in the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, is also discussed. MDPI 2022-01-25 /pmc/articles/PMC8836173/ /pubmed/35163247 http://dx.doi.org/10.3390/ijms23031323 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Grechko, Andrey V. Orekhov, Alexander N. Role of the mtDNA Mutations and Mitophagy in Inflammaging |
title | Role of the mtDNA Mutations and Mitophagy in Inflammaging |
title_full | Role of the mtDNA Mutations and Mitophagy in Inflammaging |
title_fullStr | Role of the mtDNA Mutations and Mitophagy in Inflammaging |
title_full_unstemmed | Role of the mtDNA Mutations and Mitophagy in Inflammaging |
title_short | Role of the mtDNA Mutations and Mitophagy in Inflammaging |
title_sort | role of the mtdna mutations and mitophagy in inflammaging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836173/ https://www.ncbi.nlm.nih.gov/pubmed/35163247 http://dx.doi.org/10.3390/ijms23031323 |
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