Cargando…

N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease

N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it acts as a neuromodulator of glutamatergic synapses by activating presynaptic metabotropic glutamate receptor 3 (mGluR3). Recent data suggest that NAAG is selectively localized to postsynaptic dendrites in glutam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morland, Cecilie, Nordengen, Kaja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836185/ https://www.ncbi.nlm.nih.gov/pubmed/35163193 http://dx.doi.org/10.3390/ijms23031268

Ejemplares similares

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer
por: Nguyen, Tu, et al.
Publicado: (2019)

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes
por: Kołodziejczyk, Karolina, et al.
Publicado: (2009)

Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy
por: Asaka, Ryoichi, et al.
Publicado: (2019)

Efficacy of N‐acetyl aspartyl glutamic acid versus fluorometholone for treating allergic conjunctivitis in an environmental exposure chamber
por: de Blay, Frédéric, et al.
Publicado: (2022)

N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition
por: Nagai, Takako, et al.
Publicado: (2014)

βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline
por: Gao, Rongfen, et al.
Publicado: (2019)

N‐acetyl‐seryl‐aspartyl‐lysyl‐proline is a valuable endogenous antifibrotic peptide for kidney fibrosis in diabetes: An update and translational aspects
por: Kanasaki, Keizo
Publicado: (2020)

Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors
por: Kanasaki, Megumi, et al.
Publicado: (2011)

N-acetyl-seryl-aspartyl-lysyl-proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes
por: Kanasaki, Keizo, et al.
Publicado: (2014)

N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice
por: Chan, Gary C. W., et al.
Publicado: (2015)

Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis
por: Srivastava, Swayam Prakash, et al.
Publicado: (2016)

Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica
por: Xiaojun, Wang, et al.
Publicado: (2016)

N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Mitigates Experimental Colitis Through Inhibition of Intestinal Mucosal Inflammatory Responses via MEK-ERK Signaling
por: Shi, Yingying, et al.
Publicado: (2020)

Crystal Structure of the N-Acetyltransferase Domain of Human N-Acetyl-L-Glutamate Synthase in Complex with N-Acetyl-L-Glutamate Provides Insights into Its Catalytic and Regulatory Mechanisms
por: Zhao, Gengxiang, et al.
Publicado: (2013)

Molecular characterization of a novel aspartyl aminopeptidase that contributes to the increase in glutamic acid content in chicken meat during cooking
por: Yuhara, Hitomi, et al.
Publicado: (2021)

Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain
por: Fröhlich, Dominik, et al.
Publicado: (2018)

RNA-dependent sterol aspartylation in fungi
por: Yakobov, Nathaniel, et al.
Publicado: (2020)

Signaling Functions of Intramembrane Aspartyl-Proteases
por: Papadopoulou, Alkmini A., et al.
Publicado: (2020)

Plasmepsin-like Aspartyl Proteases in Babesia
por: Šnebergerová, Pavla, et al.
Publicado: (2021)

Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen
por: Nitta, Kyoko, et al.
Publicado: (2016)

Dendritic Localization and Exocytosis of NAAG in the Rat Hippocampus
por: Nordengen, K, et al.
Publicado: (2020)

FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway
por: Li, Jinpeng, et al.
Publicado: (2017)

Aspartyl Protease Inhibitors as Anti-Filarial Drugs
por: Beld, Liana, et al.
Publicado: (2022)

Characterization of aspartyl aminopeptidase from Toxoplasma gondii
por: Zheng, Jun, et al.
Publicado: (2016)

The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis
por: Mnguni, Ayanda Trevor, et al.
Publicado: (2015)

Functional Characterization of Secreted Aspartyl Proteases in Candida parapsilosis
por: Singh, Dhirendra Kumar, et al.
Publicado: (2019)

N-Acetyl-L-glutamate Kinase of Chlamydomonas reinhardtii: In Vivo Regulation by PII Protein and Beyond
por: Vlasova, Vitalina, et al.
Publicado: (2023)

The Janus Face of VEGF in Stroke
por: Geiseler, Samuel J., et al.
Publicado: (2018)

Structural features of isomerizable aspartyl residues in human α-crystallins
por: Shimizu, Ken-ichi, et al.
Publicado: (2012)

An aspartyl protease directs malaria effector proteins to the host cell
por: Boddey, Justin A., et al.
Publicado: (2010)

Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating
por: Cassone, Antonio, et al.
Publicado: (2016)

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
por: Konstantinidou, Markella, et al.
Publicado: (2020)

Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine
por: Hoffer, Barry J., et al.
Publicado: (2017)

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors
por: Bernabucci, Matteo, et al.
Publicado: (2012)

Early care of N-acetyl glutamate synthase (NAGS) deficiency in three infants from an inbred family
por: Peoc'h, Katell, et al.
Publicado: (2020)

Partial N‐acetyl glutamate synthase deficiency presenting as postpartum hyperammonemia: Diagnosis and subsequent pregnancy management
por: Abou Haidar, Lea, et al.
Publicado: (2023)

The yapsin family of aspartyl proteases regulate glucose homeostasis in Candida glabrata
por: Askari, Fizza, et al.
Publicado: (2022)

Characterization of an antibody that recognizes peptides containing D-β-aspartyl residues
por: Aki, Kenzo, et al.
Publicado: (2012)

Localization of D-β-Aspartyl Residue-Containing Proteins in Various Tissues
por: Motoie, Ryota, et al.
Publicado: (2009)

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria
por: Goupil, Louise S., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sm2pc76hlpt8e0876tsl30kajk