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Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrog...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836214/ https://www.ncbi.nlm.nih.gov/pubmed/35163313 http://dx.doi.org/10.3390/ijms23031388 |
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author | Wagner, Kim Unger, Lucas Salman, Mootaz M. Kitchen, Philip Bill, Roslyn M. Yool, Andrea J. |
author_facet | Wagner, Kim Unger, Lucas Salman, Mootaz M. Kitchen, Philip Bill, Roslyn M. Yool, Andrea J. |
author_sort | Wagner, Kim |
collection | PubMed |
description | The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders. |
format | Online Article Text |
id | pubmed-8836214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88362142022-02-12 Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease Wagner, Kim Unger, Lucas Salman, Mootaz M. Kitchen, Philip Bill, Roslyn M. Yool, Andrea J. Int J Mol Sci Review The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders. MDPI 2022-01-26 /pmc/articles/PMC8836214/ /pubmed/35163313 http://dx.doi.org/10.3390/ijms23031388 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wagner, Kim Unger, Lucas Salman, Mootaz M. Kitchen, Philip Bill, Roslyn M. Yool, Andrea J. Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
title | Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
title_full | Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
title_fullStr | Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
title_full_unstemmed | Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
title_short | Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
title_sort | signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836214/ https://www.ncbi.nlm.nih.gov/pubmed/35163313 http://dx.doi.org/10.3390/ijms23031388 |
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