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Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrog...

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Detalles Bibliográficos
Autores principales: Wagner, Kim, Unger, Lucas, Salman, Mootaz M., Kitchen, Philip, Bill, Roslyn M., Yool, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836214/
https://www.ncbi.nlm.nih.gov/pubmed/35163313
http://dx.doi.org/10.3390/ijms23031388
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author Wagner, Kim
Unger, Lucas
Salman, Mootaz M.
Kitchen, Philip
Bill, Roslyn M.
Yool, Andrea J.
author_facet Wagner, Kim
Unger, Lucas
Salman, Mootaz M.
Kitchen, Philip
Bill, Roslyn M.
Yool, Andrea J.
author_sort Wagner, Kim
collection PubMed
description The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders.
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spelling pubmed-88362142022-02-12 Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease Wagner, Kim Unger, Lucas Salman, Mootaz M. Kitchen, Philip Bill, Roslyn M. Yool, Andrea J. Int J Mol Sci Review The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders. MDPI 2022-01-26 /pmc/articles/PMC8836214/ /pubmed/35163313 http://dx.doi.org/10.3390/ijms23031388 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wagner, Kim
Unger, Lucas
Salman, Mootaz M.
Kitchen, Philip
Bill, Roslyn M.
Yool, Andrea J.
Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
title Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
title_full Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
title_fullStr Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
title_full_unstemmed Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
title_short Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease
title_sort signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836214/
https://www.ncbi.nlm.nih.gov/pubmed/35163313
http://dx.doi.org/10.3390/ijms23031388
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