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Role of Neutrophils and NETs in Animal Models of Thrombosis
Thrombosis is one of the major causes of mortality worldwide. Notably, it is not only implicated in cardiovascular diseases, such as myocardial infarction (MI), stroke, and pulmonary embolism (PE), but also in cancers. Understanding the cellular and molecular mechanisms involved in platelet thrombus...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836215/ https://www.ncbi.nlm.nih.gov/pubmed/35163333 http://dx.doi.org/10.3390/ijms23031411 |
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author | Carminita, Estelle Crescence, Lydie Panicot-Dubois, Laurence Dubois, Christophe |
author_facet | Carminita, Estelle Crescence, Lydie Panicot-Dubois, Laurence Dubois, Christophe |
author_sort | Carminita, Estelle |
collection | PubMed |
description | Thrombosis is one of the major causes of mortality worldwide. Notably, it is not only implicated in cardiovascular diseases, such as myocardial infarction (MI), stroke, and pulmonary embolism (PE), but also in cancers. Understanding the cellular and molecular mechanisms involved in platelet thrombus formation is a major challenge for scientists today. For this purpose, new imaging technologies (such as confocal intravital microscopy, electron microscopy, holotomography, etc.) coupled with animal models of thrombosis (mouse, rat, rabbit, etc.) allow a better overview of this complex physiopathological process. Each of the cellular components is known to participate, including the subendothelial matrix, the endothelium, platelets, circulating cells, and, notably, neutrophils. Initially known as immune cells, neutrophils have been considered to be part of the landscape of thrombosis for more than a decade. They participate in this biological process through their expression of tissue factor (TF) and protein disulfide isomerase (PDI). Moreover, highly activated neutrophils are described as being able to release their DNA and thus form chromatin networks known as “neutrophil extracellular traps” (NETs). Initially, described as “dead sacrifices for a good cause” that prevent the dissemination of bacteria in the body, NETs have also been studied in several human pathologies, such as cardiovascular and respiratory diseases. Many articles suggest that they are involved in platelet thrombus formation and the activation of the coagulation cascade. This review presents the models of thrombosis in which neutrophils and NETs are involved and describes their mechanisms of action. We have even highlighted the medical diagnostic advances related to this research. |
format | Online Article Text |
id | pubmed-8836215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88362152022-02-12 Role of Neutrophils and NETs in Animal Models of Thrombosis Carminita, Estelle Crescence, Lydie Panicot-Dubois, Laurence Dubois, Christophe Int J Mol Sci Review Thrombosis is one of the major causes of mortality worldwide. Notably, it is not only implicated in cardiovascular diseases, such as myocardial infarction (MI), stroke, and pulmonary embolism (PE), but also in cancers. Understanding the cellular and molecular mechanisms involved in platelet thrombus formation is a major challenge for scientists today. For this purpose, new imaging technologies (such as confocal intravital microscopy, electron microscopy, holotomography, etc.) coupled with animal models of thrombosis (mouse, rat, rabbit, etc.) allow a better overview of this complex physiopathological process. Each of the cellular components is known to participate, including the subendothelial matrix, the endothelium, platelets, circulating cells, and, notably, neutrophils. Initially known as immune cells, neutrophils have been considered to be part of the landscape of thrombosis for more than a decade. They participate in this biological process through their expression of tissue factor (TF) and protein disulfide isomerase (PDI). Moreover, highly activated neutrophils are described as being able to release their DNA and thus form chromatin networks known as “neutrophil extracellular traps” (NETs). Initially, described as “dead sacrifices for a good cause” that prevent the dissemination of bacteria in the body, NETs have also been studied in several human pathologies, such as cardiovascular and respiratory diseases. Many articles suggest that they are involved in platelet thrombus formation and the activation of the coagulation cascade. This review presents the models of thrombosis in which neutrophils and NETs are involved and describes their mechanisms of action. We have even highlighted the medical diagnostic advances related to this research. MDPI 2022-01-26 /pmc/articles/PMC8836215/ /pubmed/35163333 http://dx.doi.org/10.3390/ijms23031411 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carminita, Estelle Crescence, Lydie Panicot-Dubois, Laurence Dubois, Christophe Role of Neutrophils and NETs in Animal Models of Thrombosis |
title | Role of Neutrophils and NETs in Animal Models of Thrombosis |
title_full | Role of Neutrophils and NETs in Animal Models of Thrombosis |
title_fullStr | Role of Neutrophils and NETs in Animal Models of Thrombosis |
title_full_unstemmed | Role of Neutrophils and NETs in Animal Models of Thrombosis |
title_short | Role of Neutrophils and NETs in Animal Models of Thrombosis |
title_sort | role of neutrophils and nets in animal models of thrombosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836215/ https://www.ncbi.nlm.nih.gov/pubmed/35163333 http://dx.doi.org/10.3390/ijms23031411 |
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