Cargando…
The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an import...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836218/ https://www.ncbi.nlm.nih.gov/pubmed/35163320 http://dx.doi.org/10.3390/ijms23031400 |
_version_ | 1784649623094165504 |
---|---|
author | Fernández-Gómez, Andrea Izquierdo, José M. |
author_facet | Fernández-Gómez, Andrea Izquierdo, José M. |
author_sort | Fernández-Gómez, Andrea |
collection | PubMed |
description | T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an important role as a regulator of gene-expression flux. As a multifunctional master modulator, TIA1 controls biological processes relevant to the physiological functioning of the organism and the development and/or progression of several human pathologies. This review summarizes our current knowledge of the molecular aspects and cellular processes involving TIA1, with relevance for human pathophysiology. |
format | Online Article Text |
id | pubmed-8836218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88362182022-02-12 The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease Fernández-Gómez, Andrea Izquierdo, José M. Int J Mol Sci Review T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an important role as a regulator of gene-expression flux. As a multifunctional master modulator, TIA1 controls biological processes relevant to the physiological functioning of the organism and the development and/or progression of several human pathologies. This review summarizes our current knowledge of the molecular aspects and cellular processes involving TIA1, with relevance for human pathophysiology. MDPI 2022-01-26 /pmc/articles/PMC8836218/ /pubmed/35163320 http://dx.doi.org/10.3390/ijms23031400 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fernández-Gómez, Andrea Izquierdo, José M. The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease |
title | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease |
title_full | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease |
title_fullStr | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease |
title_full_unstemmed | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease |
title_short | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease |
title_sort | multifunctional faces of t-cell intracellular antigen 1 in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836218/ https://www.ncbi.nlm.nih.gov/pubmed/35163320 http://dx.doi.org/10.3390/ijms23031400 |
work_keys_str_mv | AT fernandezgomezandrea themultifunctionalfacesoftcellintracellularantigen1inhealthanddisease AT izquierdojosem themultifunctionalfacesoftcellintracellularantigen1inhealthanddisease AT fernandezgomezandrea multifunctionalfacesoftcellintracellularantigen1inhealthanddisease AT izquierdojosem multifunctionalfacesoftcellintracellularantigen1inhealthanddisease |