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Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles

Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations. The PANX family has three members, PANX1, PANX2 and PANX3. Among...

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Detalles Bibliográficos
Autores principales: Yang, Kai, Xiao, Zhupeng, He, Xueai, Weng, Ruotong, Zhao, Xinyue, Sun, Taolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836264/
https://www.ncbi.nlm.nih.gov/pubmed/35163442
http://dx.doi.org/10.3390/ijms23031523
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author Yang, Kai
Xiao, Zhupeng
He, Xueai
Weng, Ruotong
Zhao, Xinyue
Sun, Taolei
author_facet Yang, Kai
Xiao, Zhupeng
He, Xueai
Weng, Ruotong
Zhao, Xinyue
Sun, Taolei
author_sort Yang, Kai
collection PubMed
description Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations. The PANX family has three members, PANX1, PANX2 and PANX3. Among them, PANX1 has been the most extensively studied. The PANX1 channels are activated by many factors, including high extracellular K(+) ([K(+)](e)), high intracellular Ca(2+) ([Ca(2+)](i)), Src family kinase (SFK)-mediated phosphorylation, caspase cleavage and mechanical stimuli. However, the mechanisms mediating this mechanosensitivity of PANX1 remain unknown. Both force-from-lipids and force-from-filaments models are proposed to explain the gating mechanisms of PANX1 channel mechanosensitivity. Finally, both the physiological and pathological roles of mechanosensitive PANX1 are discussed.
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spelling pubmed-88362642022-02-12 Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles Yang, Kai Xiao, Zhupeng He, Xueai Weng, Ruotong Zhao, Xinyue Sun, Taolei Int J Mol Sci Review Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations. The PANX family has three members, PANX1, PANX2 and PANX3. Among them, PANX1 has been the most extensively studied. The PANX1 channels are activated by many factors, including high extracellular K(+) ([K(+)](e)), high intracellular Ca(2+) ([Ca(2+)](i)), Src family kinase (SFK)-mediated phosphorylation, caspase cleavage and mechanical stimuli. However, the mechanisms mediating this mechanosensitivity of PANX1 remain unknown. Both force-from-lipids and force-from-filaments models are proposed to explain the gating mechanisms of PANX1 channel mechanosensitivity. Finally, both the physiological and pathological roles of mechanosensitive PANX1 are discussed. MDPI 2022-01-28 /pmc/articles/PMC8836264/ /pubmed/35163442 http://dx.doi.org/10.3390/ijms23031523 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Kai
Xiao, Zhupeng
He, Xueai
Weng, Ruotong
Zhao, Xinyue
Sun, Taolei
Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles
title Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles
title_full Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles
title_fullStr Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles
title_full_unstemmed Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles
title_short Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles
title_sort mechanisms of pannexin 1 (panx1) channel mechanosensitivity and its pathological roles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836264/
https://www.ncbi.nlm.nih.gov/pubmed/35163442
http://dx.doi.org/10.3390/ijms23031523
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