The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2

Several key functions of the androgen receptor (AR) such as hormone recognition and co-regulator recruitment converge in the ligand binding domain (LBD). Loss- or gain-of-function of the AR contributes to pathologies such as the androgen insensitivity syndrome and prostate cancer. Here, we describe...

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Detalles Bibliográficos
Autores principales: Helsen, Christine, Nguyen, Tien, Vercruysse, Thomas, Wouters, Staf, Daelemans, Dirk, Voet, Arnout, Claessens, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836279/
https://www.ncbi.nlm.nih.gov/pubmed/35163481
http://dx.doi.org/10.3390/ijms23031557

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