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Cell Death in AMD: The Rationale for Targeting Fas
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant need for therapies that prevent the vision loss associated wit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836408/ https://www.ncbi.nlm.nih.gov/pubmed/35160044 http://dx.doi.org/10.3390/jcm11030592 |
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author | Zacks, David N. Kocab, Andrew J. Choi, Joanne J. Gregory-Ksander, Meredith S. Cano, Marisol Handa, James T. |
author_facet | Zacks, David N. Kocab, Andrew J. Choi, Joanne J. Gregory-Ksander, Meredith S. Cano, Marisol Handa, James T. |
author_sort | Zacks, David N. |
collection | PubMed |
description | Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant need for therapies that prevent the vision loss associated with the advanced forms of dry, atrophic AMD. In this atrophic form, retinal pigment epithelial (RPE) and photoreceptor cell death is the ultimate cause of vision loss. In this review, we summarize the cell death pathways and their relation to RPE and retinal cell death in AMD. We review the data that support targeting programmed cell death through inhibition of the Fas receptor as a novel approach to preserve these structures and that this effect results from inhibiting both canonical death pathway activation and reducing the associated inflammatory response. These data lay the groundwork for current clinical strategies targeting the Fas pathway in this devastating disease. |
format | Online Article Text |
id | pubmed-8836408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88364082022-02-12 Cell Death in AMD: The Rationale for Targeting Fas Zacks, David N. Kocab, Andrew J. Choi, Joanne J. Gregory-Ksander, Meredith S. Cano, Marisol Handa, James T. J Clin Med Review Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant need for therapies that prevent the vision loss associated with the advanced forms of dry, atrophic AMD. In this atrophic form, retinal pigment epithelial (RPE) and photoreceptor cell death is the ultimate cause of vision loss. In this review, we summarize the cell death pathways and their relation to RPE and retinal cell death in AMD. We review the data that support targeting programmed cell death through inhibition of the Fas receptor as a novel approach to preserve these structures and that this effect results from inhibiting both canonical death pathway activation and reducing the associated inflammatory response. These data lay the groundwork for current clinical strategies targeting the Fas pathway in this devastating disease. MDPI 2022-01-25 /pmc/articles/PMC8836408/ /pubmed/35160044 http://dx.doi.org/10.3390/jcm11030592 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zacks, David N. Kocab, Andrew J. Choi, Joanne J. Gregory-Ksander, Meredith S. Cano, Marisol Handa, James T. Cell Death in AMD: The Rationale for Targeting Fas |
title | Cell Death in AMD: The Rationale for Targeting Fas |
title_full | Cell Death in AMD: The Rationale for Targeting Fas |
title_fullStr | Cell Death in AMD: The Rationale for Targeting Fas |
title_full_unstemmed | Cell Death in AMD: The Rationale for Targeting Fas |
title_short | Cell Death in AMD: The Rationale for Targeting Fas |
title_sort | cell death in amd: the rationale for targeting fas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836408/ https://www.ncbi.nlm.nih.gov/pubmed/35160044 http://dx.doi.org/10.3390/jcm11030592 |
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