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The Role of Sclerostin in Bone Diseases
Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin’s origin, re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836457/ https://www.ncbi.nlm.nih.gov/pubmed/35160258 http://dx.doi.org/10.3390/jcm11030806 |
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author | Vasiliadis, Elias S. Evangelopoulos, Dimitrios-Stergios Kaspiris, Angelos Benetos, Ioannis S. Vlachos, Christos Pneumaticos, Spyros G. |
author_facet | Vasiliadis, Elias S. Evangelopoulos, Dimitrios-Stergios Kaspiris, Angelos Benetos, Ioannis S. Vlachos, Christos Pneumaticos, Spyros G. |
author_sort | Vasiliadis, Elias S. |
collection | PubMed |
description | Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin’s origin, regulation, and mechanism of action. The ongoing research emphasizes the potential therapeutic implications of sclerostin in many pathological conditions with or without skeletal involvement. Antisclerostin antibodies have recently been approved for the treatment of osteoporosis, and several animal studies and clinical trials are currently under way to evaluate the effectiveness of antisclerostin antibodies in the treatment of other than osteoporosis skeletal disorders and cancer with promising results. Understanding the exact role of sclerostin may lead to new therapeutic approaches for the treatment of skeletal disorders. |
format | Online Article Text |
id | pubmed-8836457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88364572022-02-12 The Role of Sclerostin in Bone Diseases Vasiliadis, Elias S. Evangelopoulos, Dimitrios-Stergios Kaspiris, Angelos Benetos, Ioannis S. Vlachos, Christos Pneumaticos, Spyros G. J Clin Med Review Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin’s origin, regulation, and mechanism of action. The ongoing research emphasizes the potential therapeutic implications of sclerostin in many pathological conditions with or without skeletal involvement. Antisclerostin antibodies have recently been approved for the treatment of osteoporosis, and several animal studies and clinical trials are currently under way to evaluate the effectiveness of antisclerostin antibodies in the treatment of other than osteoporosis skeletal disorders and cancer with promising results. Understanding the exact role of sclerostin may lead to new therapeutic approaches for the treatment of skeletal disorders. MDPI 2022-02-02 /pmc/articles/PMC8836457/ /pubmed/35160258 http://dx.doi.org/10.3390/jcm11030806 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vasiliadis, Elias S. Evangelopoulos, Dimitrios-Stergios Kaspiris, Angelos Benetos, Ioannis S. Vlachos, Christos Pneumaticos, Spyros G. The Role of Sclerostin in Bone Diseases |
title | The Role of Sclerostin in Bone Diseases |
title_full | The Role of Sclerostin in Bone Diseases |
title_fullStr | The Role of Sclerostin in Bone Diseases |
title_full_unstemmed | The Role of Sclerostin in Bone Diseases |
title_short | The Role of Sclerostin in Bone Diseases |
title_sort | role of sclerostin in bone diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836457/ https://www.ncbi.nlm.nih.gov/pubmed/35160258 http://dx.doi.org/10.3390/jcm11030806 |
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