Cargando…

The Role of Sclerostin in Bone Diseases

Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin’s origin, re...

Descripción completa

Detalles Bibliográficos
Autores principales: Vasiliadis, Elias S., Evangelopoulos, Dimitrios-Stergios, Kaspiris, Angelos, Benetos, Ioannis S., Vlachos, Christos, Pneumaticos, Spyros G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836457/
https://www.ncbi.nlm.nih.gov/pubmed/35160258
http://dx.doi.org/10.3390/jcm11030806
_version_ 1784649684366655488
author Vasiliadis, Elias S.
Evangelopoulos, Dimitrios-Stergios
Kaspiris, Angelos
Benetos, Ioannis S.
Vlachos, Christos
Pneumaticos, Spyros G.
author_facet Vasiliadis, Elias S.
Evangelopoulos, Dimitrios-Stergios
Kaspiris, Angelos
Benetos, Ioannis S.
Vlachos, Christos
Pneumaticos, Spyros G.
author_sort Vasiliadis, Elias S.
collection PubMed
description Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin’s origin, regulation, and mechanism of action. The ongoing research emphasizes the potential therapeutic implications of sclerostin in many pathological conditions with or without skeletal involvement. Antisclerostin antibodies have recently been approved for the treatment of osteoporosis, and several animal studies and clinical trials are currently under way to evaluate the effectiveness of antisclerostin antibodies in the treatment of other than osteoporosis skeletal disorders and cancer with promising results. Understanding the exact role of sclerostin may lead to new therapeutic approaches for the treatment of skeletal disorders.
format Online
Article
Text
id pubmed-8836457
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88364572022-02-12 The Role of Sclerostin in Bone Diseases Vasiliadis, Elias S. Evangelopoulos, Dimitrios-Stergios Kaspiris, Angelos Benetos, Ioannis S. Vlachos, Christos Pneumaticos, Spyros G. J Clin Med Review Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin’s origin, regulation, and mechanism of action. The ongoing research emphasizes the potential therapeutic implications of sclerostin in many pathological conditions with or without skeletal involvement. Antisclerostin antibodies have recently been approved for the treatment of osteoporosis, and several animal studies and clinical trials are currently under way to evaluate the effectiveness of antisclerostin antibodies in the treatment of other than osteoporosis skeletal disorders and cancer with promising results. Understanding the exact role of sclerostin may lead to new therapeutic approaches for the treatment of skeletal disorders. MDPI 2022-02-02 /pmc/articles/PMC8836457/ /pubmed/35160258 http://dx.doi.org/10.3390/jcm11030806 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vasiliadis, Elias S.
Evangelopoulos, Dimitrios-Stergios
Kaspiris, Angelos
Benetos, Ioannis S.
Vlachos, Christos
Pneumaticos, Spyros G.
The Role of Sclerostin in Bone Diseases
title The Role of Sclerostin in Bone Diseases
title_full The Role of Sclerostin in Bone Diseases
title_fullStr The Role of Sclerostin in Bone Diseases
title_full_unstemmed The Role of Sclerostin in Bone Diseases
title_short The Role of Sclerostin in Bone Diseases
title_sort role of sclerostin in bone diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836457/
https://www.ncbi.nlm.nih.gov/pubmed/35160258
http://dx.doi.org/10.3390/jcm11030806
work_keys_str_mv AT vasiliadiseliass theroleofsclerostininbonediseases
AT evangelopoulosdimitriosstergios theroleofsclerostininbonediseases
AT kaspirisangelos theroleofsclerostininbonediseases
AT benetosioanniss theroleofsclerostininbonediseases
AT vlachoschristos theroleofsclerostininbonediseases
AT pneumaticosspyrosg theroleofsclerostininbonediseases
AT vasiliadiseliass roleofsclerostininbonediseases
AT evangelopoulosdimitriosstergios roleofsclerostininbonediseases
AT kaspirisangelos roleofsclerostininbonediseases
AT benetosioanniss roleofsclerostininbonediseases
AT vlachoschristos roleofsclerostininbonediseases
AT pneumaticosspyrosg roleofsclerostininbonediseases