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Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism
Introduction: Sleep bruxism (SB) is a widespread masticatory muscle activity during sleep and affects approximately 13.2% of the general population. Telomerase reverse transcriptase (TERT) plays a role in preventing the shortening of the telomere. This prospective, observational study aimed to inves...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836512/ https://www.ncbi.nlm.nih.gov/pubmed/35159976 http://dx.doi.org/10.3390/jcm11030525 |
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author | Macek, Piotr Wieckiewicz, Mieszko Poreba, Rafal Gac, Pawel Bogunia-Kubik, Katarzyna Dratwa, Marta Wojakowska, Anna Mazur, Grzegorz Martynowicz, Helena |
author_facet | Macek, Piotr Wieckiewicz, Mieszko Poreba, Rafal Gac, Pawel Bogunia-Kubik, Katarzyna Dratwa, Marta Wojakowska, Anna Mazur, Grzegorz Martynowicz, Helena |
author_sort | Macek, Piotr |
collection | PubMed |
description | Introduction: Sleep bruxism (SB) is a widespread masticatory muscle activity during sleep and affects approximately 13.2% of the general population. Telomerase reverse transcriptase (TERT) plays a role in preventing the shortening of the telomere. This prospective, observational study aimed to investigate the relationship between single nucleotide polymorphism (SNP) of TERT and the severity of SB and to identify the independent risk factors for SB. Methods: A total of 112 patients were diagnosed by performing one-night polysomnography based on the guidelines of the American Academy of Sleep Medicine. TERT SNP was detected by real-time quantitative polymerase chain reaction (qPCR). Results: Statistical analysis showed the lack of relationship between the rs2853669 polymorphism of TERT and severity of SB (p > 0.05). However, the study showed that patients with allele T in the 2736100 polymorphism of TERT had a lower score on the phasic bruxism episode index (BEI). Based on the receiver operating characteristic (ROC) curve, the value of phasic BEI was 0.8 for the differential prediction for the presence of allele T in the locus. The sensitivity and specificity were 0.328 and 0.893, respectively. The regression analysis showed that lack of TERT rs2736100 T allele, male gender, and arterial hypertension are the risk factors for the higher value of phasic BEI. Conclusion: The SNP of the TERT gene affects phasic SB intensity. The absence of TERT rs2736100 T allele, male sex, and arterial hypertension are independent risk factors for phasic SB. |
format | Online Article Text |
id | pubmed-8836512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88365122022-02-12 Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism Macek, Piotr Wieckiewicz, Mieszko Poreba, Rafal Gac, Pawel Bogunia-Kubik, Katarzyna Dratwa, Marta Wojakowska, Anna Mazur, Grzegorz Martynowicz, Helena J Clin Med Article Introduction: Sleep bruxism (SB) is a widespread masticatory muscle activity during sleep and affects approximately 13.2% of the general population. Telomerase reverse transcriptase (TERT) plays a role in preventing the shortening of the telomere. This prospective, observational study aimed to investigate the relationship between single nucleotide polymorphism (SNP) of TERT and the severity of SB and to identify the independent risk factors for SB. Methods: A total of 112 patients were diagnosed by performing one-night polysomnography based on the guidelines of the American Academy of Sleep Medicine. TERT SNP was detected by real-time quantitative polymerase chain reaction (qPCR). Results: Statistical analysis showed the lack of relationship between the rs2853669 polymorphism of TERT and severity of SB (p > 0.05). However, the study showed that patients with allele T in the 2736100 polymorphism of TERT had a lower score on the phasic bruxism episode index (BEI). Based on the receiver operating characteristic (ROC) curve, the value of phasic BEI was 0.8 for the differential prediction for the presence of allele T in the locus. The sensitivity and specificity were 0.328 and 0.893, respectively. The regression analysis showed that lack of TERT rs2736100 T allele, male gender, and arterial hypertension are the risk factors for the higher value of phasic BEI. Conclusion: The SNP of the TERT gene affects phasic SB intensity. The absence of TERT rs2736100 T allele, male sex, and arterial hypertension are independent risk factors for phasic SB. MDPI 2022-01-20 /pmc/articles/PMC8836512/ /pubmed/35159976 http://dx.doi.org/10.3390/jcm11030525 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Macek, Piotr Wieckiewicz, Mieszko Poreba, Rafal Gac, Pawel Bogunia-Kubik, Katarzyna Dratwa, Marta Wojakowska, Anna Mazur, Grzegorz Martynowicz, Helena Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism |
title | Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism |
title_full | Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism |
title_fullStr | Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism |
title_full_unstemmed | Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism |
title_short | Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism |
title_sort | assessment of telomerase reverse transcriptase single nucleotide polymorphism in sleep bruxism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836512/ https://www.ncbi.nlm.nih.gov/pubmed/35159976 http://dx.doi.org/10.3390/jcm11030525 |
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