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Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study

Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characte...

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Autores principales: Méndez-Bailón, Manuel, Lorenzo-Villalba, Noel, Romero-Correa, Miriam, Guisado-Espartero, Esther, González-Soler, Juan, Rugeles-Niño, Jessica, Sebastián-Leza, Angel, Ceresuela-Eito, Luis, Romaní-Costa, Verónica, Quesada-Simón, Angustias, Soler-Rangel, Llanos, Herrero-Domingo, Almudena, Díez-García, Luis, Alcalá-Pedrajas, José, Villalonga-Comas, María, Andrès, Emmanuel, Gudiñ-Aguirre, Diego, Formiga, Francesc, Aramburu-Bodas, Oscar, Arias-Jiménez, Jose, Salamanca-Bautista, Prado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836514/
https://www.ncbi.nlm.nih.gov/pubmed/35160023
http://dx.doi.org/10.3390/jcm11030571
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author Méndez-Bailón, Manuel
Lorenzo-Villalba, Noel
Romero-Correa, Miriam
Guisado-Espartero, Esther
González-Soler, Juan
Rugeles-Niño, Jessica
Sebastián-Leza, Angel
Ceresuela-Eito, Luis
Romaní-Costa, Verónica
Quesada-Simón, Angustias
Soler-Rangel, Llanos
Herrero-Domingo, Almudena
Díez-García, Luis
Alcalá-Pedrajas, José
Villalonga-Comas, María
Andrès, Emmanuel
Gudiñ-Aguirre, Diego
Formiga, Francesc
Aramburu-Bodas, Oscar
Arias-Jiménez, Jose
Salamanca-Bautista, Prado
author_facet Méndez-Bailón, Manuel
Lorenzo-Villalba, Noel
Romero-Correa, Miriam
Guisado-Espartero, Esther
González-Soler, Juan
Rugeles-Niño, Jessica
Sebastián-Leza, Angel
Ceresuela-Eito, Luis
Romaní-Costa, Verónica
Quesada-Simón, Angustias
Soler-Rangel, Llanos
Herrero-Domingo, Almudena
Díez-García, Luis
Alcalá-Pedrajas, José
Villalonga-Comas, María
Andrès, Emmanuel
Gudiñ-Aguirre, Diego
Formiga, Francesc
Aramburu-Bodas, Oscar
Arias-Jiménez, Jose
Salamanca-Bautista, Prado
author_sort Méndez-Bailón, Manuel
collection PubMed
description Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan–Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. Results: A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (p = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, p = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, p = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), p = 0.046. Conclusion: Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis.
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spelling pubmed-88365142022-02-12 Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study Méndez-Bailón, Manuel Lorenzo-Villalba, Noel Romero-Correa, Miriam Guisado-Espartero, Esther González-Soler, Juan Rugeles-Niño, Jessica Sebastián-Leza, Angel Ceresuela-Eito, Luis Romaní-Costa, Verónica Quesada-Simón, Angustias Soler-Rangel, Llanos Herrero-Domingo, Almudena Díez-García, Luis Alcalá-Pedrajas, José Villalonga-Comas, María Andrès, Emmanuel Gudiñ-Aguirre, Diego Formiga, Francesc Aramburu-Bodas, Oscar Arias-Jiménez, Jose Salamanca-Bautista, Prado J Clin Med Article Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan–Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. Results: A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (p = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, p = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, p = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), p = 0.046. Conclusion: Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis. MDPI 2022-01-24 /pmc/articles/PMC8836514/ /pubmed/35160023 http://dx.doi.org/10.3390/jcm11030571 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Méndez-Bailón, Manuel
Lorenzo-Villalba, Noel
Romero-Correa, Miriam
Guisado-Espartero, Esther
González-Soler, Juan
Rugeles-Niño, Jessica
Sebastián-Leza, Angel
Ceresuela-Eito, Luis
Romaní-Costa, Verónica
Quesada-Simón, Angustias
Soler-Rangel, Llanos
Herrero-Domingo, Almudena
Díez-García, Luis
Alcalá-Pedrajas, José
Villalonga-Comas, María
Andrès, Emmanuel
Gudiñ-Aguirre, Diego
Formiga, Francesc
Aramburu-Bodas, Oscar
Arias-Jiménez, Jose
Salamanca-Bautista, Prado
Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
title Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
title_full Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
title_fullStr Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
title_full_unstemmed Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
title_short Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study
title_sort cancer impacts prognosis on mortality in patients with acute heart failure: analysis of the epicter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836514/
https://www.ncbi.nlm.nih.gov/pubmed/35160023
http://dx.doi.org/10.3390/jcm11030571
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