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Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification

c-Myc is an oncogene that is dysregulated in various cancers. Early gastric neoplasia with c-Myc expression has been reported as a more malignant lesion. This study clarifies the differences in c-Myc expression in early gastric neoplasia based on the WHO classification. Samples from 100 patients wit...

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Autores principales: Arakawa, Noriyuki, Irisawa, Atsushi, Ishida, Kazuyuki, Tsunoda, Takuya, Yamaguchi, Yoshiko, Shibukawa, Goro, Eizuka, Makoto, Tokioka, Shunzo, Wakabayashi, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836573/
https://www.ncbi.nlm.nih.gov/pubmed/35159995
http://dx.doi.org/10.3390/jcm11030544
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author Arakawa, Noriyuki
Irisawa, Atsushi
Ishida, Kazuyuki
Tsunoda, Takuya
Yamaguchi, Yoshiko
Shibukawa, Goro
Eizuka, Makoto
Tokioka, Shunzo
Wakabayashi, Hiroto
author_facet Arakawa, Noriyuki
Irisawa, Atsushi
Ishida, Kazuyuki
Tsunoda, Takuya
Yamaguchi, Yoshiko
Shibukawa, Goro
Eizuka, Makoto
Tokioka, Shunzo
Wakabayashi, Hiroto
author_sort Arakawa, Noriyuki
collection PubMed
description c-Myc is an oncogene that is dysregulated in various cancers. Early gastric neoplasia with c-Myc expression has been reported as a more malignant lesion. This study clarifies the differences in c-Myc expression in early gastric neoplasia based on the WHO classification. Samples from 100 patients with differentiated-type early gastric neoplasia, who underwent endoscopic submucosal dissection between March 2020 and January 2021, were stained for c-Myc. One hundred lesions were classified as low-grade dysplasia, high-grade dysplasia, or intramucosal adenocarcinoma. The staining intensity and extent were scored. A hierarchical cluster analysis for a clinicopathological analysis among the groups, the chi-square test, Bonferroni correction, and residual analysis were performed. Subgroup one and two consisted of 39 patients; while subgroup three consisted of 22. Significant differences among various characteristics were observed between these subgroups. The frequency of low-grade dysplasia was significantly higher, while that of high-grade dysplasia was significantly lower in subgroup three. The frequency of intramucosal adenocarcinoma was significantly higher in subgroup one. The c-Myc positivity rate was significantly higher in subgroup one compared with that in subgroup three. c-Myc expression distinctly differed in early gastric neoplasia. c-Myc-negative low-grade dysplasia may be separately categorized from c-Myc-positive low-grade dysplasia, high-grade dysplasia, and intramucosal adenocarcinoma.
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spelling pubmed-88365732022-02-12 Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification Arakawa, Noriyuki Irisawa, Atsushi Ishida, Kazuyuki Tsunoda, Takuya Yamaguchi, Yoshiko Shibukawa, Goro Eizuka, Makoto Tokioka, Shunzo Wakabayashi, Hiroto J Clin Med Article c-Myc is an oncogene that is dysregulated in various cancers. Early gastric neoplasia with c-Myc expression has been reported as a more malignant lesion. This study clarifies the differences in c-Myc expression in early gastric neoplasia based on the WHO classification. Samples from 100 patients with differentiated-type early gastric neoplasia, who underwent endoscopic submucosal dissection between March 2020 and January 2021, were stained for c-Myc. One hundred lesions were classified as low-grade dysplasia, high-grade dysplasia, or intramucosal adenocarcinoma. The staining intensity and extent were scored. A hierarchical cluster analysis for a clinicopathological analysis among the groups, the chi-square test, Bonferroni correction, and residual analysis were performed. Subgroup one and two consisted of 39 patients; while subgroup three consisted of 22. Significant differences among various characteristics were observed between these subgroups. The frequency of low-grade dysplasia was significantly higher, while that of high-grade dysplasia was significantly lower in subgroup three. The frequency of intramucosal adenocarcinoma was significantly higher in subgroup one. The c-Myc positivity rate was significantly higher in subgroup one compared with that in subgroup three. c-Myc expression distinctly differed in early gastric neoplasia. c-Myc-negative low-grade dysplasia may be separately categorized from c-Myc-positive low-grade dysplasia, high-grade dysplasia, and intramucosal adenocarcinoma. MDPI 2022-01-21 /pmc/articles/PMC8836573/ /pubmed/35159995 http://dx.doi.org/10.3390/jcm11030544 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arakawa, Noriyuki
Irisawa, Atsushi
Ishida, Kazuyuki
Tsunoda, Takuya
Yamaguchi, Yoshiko
Shibukawa, Goro
Eizuka, Makoto
Tokioka, Shunzo
Wakabayashi, Hiroto
Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification
title Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification
title_full Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification
title_fullStr Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification
title_full_unstemmed Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification
title_short Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification
title_sort clinical differences in c-myc expression in early-stage gastric neoplasia: a retrospective study based on the who classification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836573/
https://www.ncbi.nlm.nih.gov/pubmed/35159995
http://dx.doi.org/10.3390/jcm11030544
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