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Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract

Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases,...

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Autores principales: Cipollina, Chiara, Bruno, Andreina, Fasola, Salvatore, Cristaldi, Marta, Patella, Bernardo, Inguanta, Rosalinda, Vilasi, Antonio, Aiello, Giuseppe, La Grutta, Stefania, Torino, Claudia, Pace, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836577/
https://www.ncbi.nlm.nih.gov/pubmed/35163691
http://dx.doi.org/10.3390/ijms23031770
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author Cipollina, Chiara
Bruno, Andreina
Fasola, Salvatore
Cristaldi, Marta
Patella, Bernardo
Inguanta, Rosalinda
Vilasi, Antonio
Aiello, Giuseppe
La Grutta, Stefania
Torino, Claudia
Pace, Elisabetta
author_facet Cipollina, Chiara
Bruno, Andreina
Fasola, Salvatore
Cristaldi, Marta
Patella, Bernardo
Inguanta, Rosalinda
Vilasi, Antonio
Aiello, Giuseppe
La Grutta, Stefania
Torino, Claudia
Pace, Elisabetta
author_sort Cipollina, Chiara
collection PubMed
description Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). Increased oxidative stress leads to exhaustion of antioxidant defenses, alterations in autophagy/mitophagy and cell survival regulatory mechanisms, thus promoting cell senescence. All these events are amplified by the increase of inflammation driven by oxidative stress. Several models of bronchial epithelial cells are used to study the molecular mechanisms and the cellular functions altered by cigarette smoke extract (CSE) exposure, and to test the efficacy of molecules with antioxidant properties. This review offers a comprehensive synthesis of human in-vitro and ex-vivo studies published from 2011 to 2021 describing the molecular and cellular mechanisms evoked by CSE exposure in bronchial epithelial cells, the most used experimental models and the mechanisms of action of cellular antioxidants systems as well as natural and synthetic antioxidant compounds.
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spelling pubmed-88365772022-02-12 Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract Cipollina, Chiara Bruno, Andreina Fasola, Salvatore Cristaldi, Marta Patella, Bernardo Inguanta, Rosalinda Vilasi, Antonio Aiello, Giuseppe La Grutta, Stefania Torino, Claudia Pace, Elisabetta Int J Mol Sci Review Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). Increased oxidative stress leads to exhaustion of antioxidant defenses, alterations in autophagy/mitophagy and cell survival regulatory mechanisms, thus promoting cell senescence. All these events are amplified by the increase of inflammation driven by oxidative stress. Several models of bronchial epithelial cells are used to study the molecular mechanisms and the cellular functions altered by cigarette smoke extract (CSE) exposure, and to test the efficacy of molecules with antioxidant properties. This review offers a comprehensive synthesis of human in-vitro and ex-vivo studies published from 2011 to 2021 describing the molecular and cellular mechanisms evoked by CSE exposure in bronchial epithelial cells, the most used experimental models and the mechanisms of action of cellular antioxidants systems as well as natural and synthetic antioxidant compounds. MDPI 2022-02-04 /pmc/articles/PMC8836577/ /pubmed/35163691 http://dx.doi.org/10.3390/ijms23031770 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cipollina, Chiara
Bruno, Andreina
Fasola, Salvatore
Cristaldi, Marta
Patella, Bernardo
Inguanta, Rosalinda
Vilasi, Antonio
Aiello, Giuseppe
La Grutta, Stefania
Torino, Claudia
Pace, Elisabetta
Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
title Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
title_full Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
title_fullStr Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
title_full_unstemmed Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
title_short Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
title_sort cellular and molecular signatures of oxidative stress in bronchial epithelial cell models injured by cigarette smoke extract
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836577/
https://www.ncbi.nlm.nih.gov/pubmed/35163691
http://dx.doi.org/10.3390/ijms23031770
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