Cargando…

COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidbauer, Moritz L., Ferse, Caroline, Salih, Farid, Klingner, Carsten, Musleh, Rita, Kunst, Stefan, Wittstock, Matthias, Neumann, Bernhard, Schebesch, Karl-Michael, Bösel, Julian, Godau, Jana, Lochner, Piergiorgio, Adam, Elisabeth H., Jahnke, Kolja, Knier, Benjamin, Schirotzek, Ingo, Müllges, Wolfgang, Notz, Quirin, Dengl, Markus, Güldner, Andreas, Onur, Oezguer A., Garcia Borrega, Jorge, Dimitriadis, Konstantinos, Günther, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836638/
https://www.ncbi.nlm.nih.gov/pubmed/35160057
http://dx.doi.org/10.3390/jcm11030605
_version_ 1784649729093664768
author Schmidbauer, Moritz L.
Ferse, Caroline
Salih, Farid
Klingner, Carsten
Musleh, Rita
Kunst, Stefan
Wittstock, Matthias
Neumann, Bernhard
Schebesch, Karl-Michael
Bösel, Julian
Godau, Jana
Lochner, Piergiorgio
Adam, Elisabeth H.
Jahnke, Kolja
Knier, Benjamin
Schirotzek, Ingo
Müllges, Wolfgang
Notz, Quirin
Dengl, Markus
Güldner, Andreas
Onur, Oezguer A.
Garcia Borrega, Jorge
Dimitriadis, Konstantinos
Günther, Albrecht
author_facet Schmidbauer, Moritz L.
Ferse, Caroline
Salih, Farid
Klingner, Carsten
Musleh, Rita
Kunst, Stefan
Wittstock, Matthias
Neumann, Bernhard
Schebesch, Karl-Michael
Bösel, Julian
Godau, Jana
Lochner, Piergiorgio
Adam, Elisabeth H.
Jahnke, Kolja
Knier, Benjamin
Schirotzek, Ingo
Müllges, Wolfgang
Notz, Quirin
Dengl, Markus
Güldner, Andreas
Onur, Oezguer A.
Garcia Borrega, Jorge
Dimitriadis, Konstantinos
Günther, Albrecht
author_sort Schmidbauer, Moritz L.
collection PubMed
description Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological subtypes, and clinical characteristics of intracranial hemorrhage (ICH) in coronavirus disease (COVID-19) patients. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the literature by screening the PubMed database and included patients diagnosed with COVID-19 and concomitant ICH. We performed a pooled analysis, including a prospectively collected cohort of critically ill COVID-19 patients with ICH, as part of the PANDEMIC registry (Pooled Analysis of Neurologic Disorders Manifesting in Intensive Care of COVID-19). Results: Our literature review revealed a total of 217 citations. After the selection process, 79 studies and a total of 477 patients were included. The median age was 58.8 years. A total of 23.3% of patients experienced the critical stage of COVID-19, 62.7% of patients were on anticoagulation and 27.5% of the patients received ECMO. The prevalence of ICH was at 0.85% and the mortality at 52.18%, respectively. Conclusion: ICH in COVID-19 patients is rare, but it has a very poor prognosis. Different subtypes of ICH seen in COVID-19, support the assumption of heterogeneous and multifaceted pathomechanisms contributing to ICH in COVID-19. Further clinical and pathophysiological investigations are warranted to resolve the conflict between thromboembolic and hemorrhagic complications in the future.
format Online
Article
Text
id pubmed-8836638
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88366382022-02-12 COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis Schmidbauer, Moritz L. Ferse, Caroline Salih, Farid Klingner, Carsten Musleh, Rita Kunst, Stefan Wittstock, Matthias Neumann, Bernhard Schebesch, Karl-Michael Bösel, Julian Godau, Jana Lochner, Piergiorgio Adam, Elisabeth H. Jahnke, Kolja Knier, Benjamin Schirotzek, Ingo Müllges, Wolfgang Notz, Quirin Dengl, Markus Güldner, Andreas Onur, Oezguer A. Garcia Borrega, Jorge Dimitriadis, Konstantinos Günther, Albrecht J Clin Med Article Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological subtypes, and clinical characteristics of intracranial hemorrhage (ICH) in coronavirus disease (COVID-19) patients. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the literature by screening the PubMed database and included patients diagnosed with COVID-19 and concomitant ICH. We performed a pooled analysis, including a prospectively collected cohort of critically ill COVID-19 patients with ICH, as part of the PANDEMIC registry (Pooled Analysis of Neurologic Disorders Manifesting in Intensive Care of COVID-19). Results: Our literature review revealed a total of 217 citations. After the selection process, 79 studies and a total of 477 patients were included. The median age was 58.8 years. A total of 23.3% of patients experienced the critical stage of COVID-19, 62.7% of patients were on anticoagulation and 27.5% of the patients received ECMO. The prevalence of ICH was at 0.85% and the mortality at 52.18%, respectively. Conclusion: ICH in COVID-19 patients is rare, but it has a very poor prognosis. Different subtypes of ICH seen in COVID-19, support the assumption of heterogeneous and multifaceted pathomechanisms contributing to ICH in COVID-19. Further clinical and pathophysiological investigations are warranted to resolve the conflict between thromboembolic and hemorrhagic complications in the future. MDPI 2022-01-25 /pmc/articles/PMC8836638/ /pubmed/35160057 http://dx.doi.org/10.3390/jcm11030605 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schmidbauer, Moritz L.
Ferse, Caroline
Salih, Farid
Klingner, Carsten
Musleh, Rita
Kunst, Stefan
Wittstock, Matthias
Neumann, Bernhard
Schebesch, Karl-Michael
Bösel, Julian
Godau, Jana
Lochner, Piergiorgio
Adam, Elisabeth H.
Jahnke, Kolja
Knier, Benjamin
Schirotzek, Ingo
Müllges, Wolfgang
Notz, Quirin
Dengl, Markus
Güldner, Andreas
Onur, Oezguer A.
Garcia Borrega, Jorge
Dimitriadis, Konstantinos
Günther, Albrecht
COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
title COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
title_full COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
title_fullStr COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
title_full_unstemmed COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
title_short COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
title_sort covid-19 and intracranial hemorrhage: a multicenter case series, systematic review and pooled analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836638/
https://www.ncbi.nlm.nih.gov/pubmed/35160057
http://dx.doi.org/10.3390/jcm11030605
work_keys_str_mv AT schmidbauermoritzl covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT fersecaroline covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT salihfarid covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT klingnercarsten covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT muslehrita covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT kunststefan covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT wittstockmatthias covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT neumannbernhard covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT schebeschkarlmichael covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT boseljulian covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT godaujana covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT lochnerpiergiorgio covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT adamelisabethh covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT jahnkekolja covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT knierbenjamin covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT schirotzekingo covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT mullgeswolfgang covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT notzquirin covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT denglmarkus covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT guldnerandreas covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT onuroezguera covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT garciaborregajorge covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT dimitriadiskonstantinos covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT guntheralbrecht covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis
AT covid19andintracranialhemorrhageamulticentercaseseriessystematicreviewandpooledanalysis