Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects

Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Yuwen, Li, Manrui, Cao, Shuqiang, Xu, Yang, Wu, Peiyan, Xu, Shuting, Pan, Qian, Guo, Yadong, Ye, Yi, Wang, Zheng, Dai, Hao, Xie, Xiaoqi, Chen, Xiameng, Liang, Weibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836693/
https://www.ncbi.nlm.nih.gov/pubmed/35163726
http://dx.doi.org/10.3390/ijms23031800
_version_ 1784649742961082368
author Sun, Yuwen
Li, Manrui
Cao, Shuqiang
Xu, Yang
Wu, Peiyan
Xu, Shuting
Pan, Qian
Guo, Yadong
Ye, Yi
Wang, Zheng
Dai, Hao
Xie, Xiaoqi
Chen, Xiameng
Liang, Weibo
author_facet Sun, Yuwen
Li, Manrui
Cao, Shuqiang
Xu, Yang
Wu, Peiyan
Xu, Shuting
Pan, Qian
Guo, Yadong
Ye, Yi
Wang, Zheng
Dai, Hao
Xie, Xiaoqi
Chen, Xiameng
Liang, Weibo
author_sort Sun, Yuwen
collection PubMed
description Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not without its own limitations. In this review, we narratively review the latest research on the improvement and existing challenges of optogenetics, with a particular focus on the field of brain injury, aiming at advancing optogenetics in the study of brain injury and collating the issues that remain. Finally, we review the most current examples of research, applying photostimulation in clinical treatment, and we explore the future prospects of these technologies.
format Online
Article
Text
id pubmed-8836693
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88366932022-02-12 Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects Sun, Yuwen Li, Manrui Cao, Shuqiang Xu, Yang Wu, Peiyan Xu, Shuting Pan, Qian Guo, Yadong Ye, Yi Wang, Zheng Dai, Hao Xie, Xiaoqi Chen, Xiameng Liang, Weibo Int J Mol Sci Review Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not without its own limitations. In this review, we narratively review the latest research on the improvement and existing challenges of optogenetics, with a particular focus on the field of brain injury, aiming at advancing optogenetics in the study of brain injury and collating the issues that remain. Finally, we review the most current examples of research, applying photostimulation in clinical treatment, and we explore the future prospects of these technologies. MDPI 2022-02-04 /pmc/articles/PMC8836693/ /pubmed/35163726 http://dx.doi.org/10.3390/ijms23031800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Yuwen
Li, Manrui
Cao, Shuqiang
Xu, Yang
Wu, Peiyan
Xu, Shuting
Pan, Qian
Guo, Yadong
Ye, Yi
Wang, Zheng
Dai, Hao
Xie, Xiaoqi
Chen, Xiameng
Liang, Weibo
Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
title Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
title_full Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
title_fullStr Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
title_full_unstemmed Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
title_short Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
title_sort optogenetics for understanding and treating brain injury: advances in the field and future prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836693/
https://www.ncbi.nlm.nih.gov/pubmed/35163726
http://dx.doi.org/10.3390/ijms23031800
work_keys_str_mv AT sunyuwen optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT limanrui optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT caoshuqiang optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT xuyang optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT wupeiyan optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT xushuting optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT panqian optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT guoyadong optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT yeyi optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT wangzheng optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT daihao optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT xiexiaoqi optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT chenxiameng optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects
AT liangweibo optogeneticsforunderstandingandtreatingbraininjuryadvancesinthefieldandfutureprospects

Ejemplares similares