Cargando…

Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke

Globally, stroke is a leading cause of death and long-term disability. Over the past decades, several efforts have attempted to discover new drugs or repurpose existing therapeutics to promote post-stroke neurological recovery. Preclinical stroke studies have reported successes in identifying novel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nilles, Kelsy L., Williams, Erica I., Betterton, Robert D., Davis, Thomas P., Ronaldson, Patrick T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836701/ https://www.ncbi.nlm.nih.gov/pubmed/35163820 http://dx.doi.org/10.3390/ijms23031898

Ejemplares similares

Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke
por: Williams, Erica I., et al.
Publicado: (2020)

High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats
por: Yang, Junzhi, et al.
Publicado: (2022)

Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke
por: Brzica, Hrvoje, et al.
Publicado: (2017)

Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity
por: Yang, Junzhi, et al.
Publicado: (2018)

Transport Mechanisms at the Blood–Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs
por: Ronaldson, Patrick T., et al.
Publicado: (2022)

Occludin regulation of blood–brain barrier and potential therapeutic target in ischemic stroke
por: Yuan, Shuhua, et al.
Publicado: (2020)

High Resolution Multiplex Confocal Imaging of the Neurovascular Unit in Health and Experimental Ischemic Stroke
por: Lochhead, Jeffrey J., et al.
Publicado: (2023)

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders
por: Lochhead, Jeffrey J., et al.
Publicado: (2020)

Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke
por: Lakhan, Shaheen E., et al.
Publicado: (2013)

Evolution of blood-brain-barrier permeability after acute ischemic stroke
por: Merali, Zamir, et al.
Publicado: (2017)

Role of NADPH Oxidases in Blood–Brain Barrier Disruption and Ischemic Stroke
por: Hernandes, Marina S., et al.
Publicado: (2022)

Blood-brain barrier dysfunction in ischemic stroke and diabetes: the underlying link, mechanisms and future possible therapeutic targets
por: Wicha, Piyawadee, et al.
Publicado: (2021)

Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats
por: Brzica, Hrvoje, et al.
Publicado: (2018)

Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics
por: de Lange, Elizabeth C. M., et al.
Publicado: (2022)

Corrigendum: Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke
por: Lakhan, Shaheen E., et al.
Publicado: (2018)

Blood-Brain Barrier Damage in Ischemic Stroke and Its Regulation by Endothelial Mechanotransduction
por: Nian, Keqing, et al.
Publicado: (2020)

AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke
por: Seo, Ji Hae, et al.
Publicado: (2020)

Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier
por: Alonso-Alonso, Maria Luz, et al.
Publicado: (2022)

Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke
por: Gao, Hui-min, et al.
Publicado: (2023)

Blood-Brain Barrier Alterations Provide Evidence of Subacute Diaschisis in an Ischemic Stroke Rat Model
por: Garbuzova-Davis, Svitlana, et al.
Publicado: (2013)

Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood–Brain Barrier Disruption after Ischemic Stroke
por: Li, Fengwu, et al.
Publicado: (2018)

Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke
por: Kim, Jeong-Hyeon, et al.
Publicado: (2013)

Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke
por: Liu, Yu-Chuan, et al.
Publicado: (2018)

Beneficial Role of Rosuvastatin in Blood–Brain Barrier Damage Following Experimental Ischemic Stroke
por: Lu, Dan, et al.
Publicado: (2018)

Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke
por: Li, Juan, et al.
Publicado: (2018)

Caveolae-Mediated Endothelial Transcytosis across the Blood-Brain Barrier in Acute Ischemic Stroke
por: Zhou, Min, et al.
Publicado: (2021)

AIM2 deletion enhances blood‐brain barrier integrity in experimental ischemic stroke
por: Xu, Si‐yi, et al.
Publicado: (2021)

Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke
por: Parvez, Suhel, et al.
Publicado: (2022)

Curcumin ameliorates ischemic stroke injury in rats by protecting the integrity of the blood-brain barrier
por: Wu, Shuguang, et al.
Publicado: (2021)

Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations
por: Zgavc, Tine, et al.
Publicado: (2011)

Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke
por: Jin, Albert Y, et al.
Publicado: (2010)

Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke
por: Spitzer, Daniel, et al.
Publicado: (2022)

Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood–brain barrier following hypoxia-reoxygenation stress
por: Ibbotson, Kathryn, et al.
Publicado: (2017)

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke
por: Turner, Renée J., et al.
Publicado: (2016)

Temporal changes in blood–brain barrier permeability and cerebral perfusion in lacunar/subcortical ischemic stroke
por: Yang, Jun, et al.
Publicado: (2015)

TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke
por: Liu, Pin-yi, et al.
Publicado: (2019)

The Effects and Underlying Mechanisms of Cell Therapy on Blood-Brain Barrier Integrity After Ischemic Stroke
por: Gao, Li, et al.
Publicado: (2020)

VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke
por: Hu, Yue, et al.
Publicado: (2022)

Storax Inhibits Caveolae-Mediated Transcytosis at Blood-Brain Barrier After Ischemic Stroke in Rats
por: Zhou, Min, et al.
Publicado: (2022)

Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke
por: Pan, Rong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3r9eqvb2n8egc9rh45tvul4oac