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The pore conformation of lymphocyte perforin

Perforin is a pore-forming protein that facilitates rapid killing of pathogen-infected or cancerous cells by the immune system. Perforin is released from cytotoxic lymphocytes, together with proapoptotic granzymes, to bind to a target cell membrane where it oligomerizes and forms pores. The pores al...

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Detalles Bibliográficos
Autores principales:	Ivanova, Marina E., Lukoyanova, Natalya, Malhotra, Sony, Topf, Maya, Trapani, Joseph A., Voskoboinik, Ilia, Saibil, Helen R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836823/ https://www.ncbi.nlm.nih.gov/pubmed/35148176 http://dx.doi.org/10.1126/sciadv.abk3147

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