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Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms
Coil embolization has become a well-established option for the treatment of intracranial aneurysms. Yet, wide-neck bifurcation aneurysms (WNBAs) remain a challenge. The pCONUS is the first generation of a stent-like implant for the bridging of WNBAs to enable coiling. The pToWin study was a prospect...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836830/ https://www.ncbi.nlm.nih.gov/pubmed/35160333 http://dx.doi.org/10.3390/jcm11030884 |
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author | Aguilar Pérez, Marta Henkes, Hans Kurre, Wiebke Bleise, Carlos Lylyk, Pedro Nicolás Lundquist, Javier Turjman, Francis Alhazmi, Hanan Loehr, Christian Felber, Stephan Deutschmann, Hannes Lowens, Stephan Delehaye, Luigi Möhlenbruch, Markus Hattingen, Jörg Lylyk, Pedro |
author_facet | Aguilar Pérez, Marta Henkes, Hans Kurre, Wiebke Bleise, Carlos Lylyk, Pedro Nicolás Lundquist, Javier Turjman, Francis Alhazmi, Hanan Loehr, Christian Felber, Stephan Deutschmann, Hannes Lowens, Stephan Delehaye, Luigi Möhlenbruch, Markus Hattingen, Jörg Lylyk, Pedro |
author_sort | Aguilar Pérez, Marta |
collection | PubMed |
description | Coil embolization has become a well-established option for the treatment of intracranial aneurysms. Yet, wide-neck bifurcation aneurysms (WNBAs) remain a challenge. The pCONUS is the first generation of a stent-like implant for the bridging of WNBAs to enable coiling. The pToWin study was a prospective, single-arm, multicenter study conducted to analyze the safety and efficacy of the pCONUS in the treatment of WNBAs. The primary effectiveness endpoint was the rate of adequate occlusion of the aneurysm at 3–6 and 7–12 months. The primary safety endpoint was the occurrence of major ipsilateral stroke or neurological death during the follow-up. A total of 115 patients were included. Aneurysm locations were the middle cerebral artery in 52 (45.2%), the anterior communicating artery in 35 (30.4%), the basilar artery in 23 (20%), the internal carotid artery terminus in three (2.6%), and the pericallosal artery in two (1.7%) patients. Treatment was successfully performed in all but one patient. The morbi-mortality rate was 1.9% and 2.3% at 3–6 and 7–12 months, respectively. Of the aneurysms, 75.0% and 65.6% showed adequate occlusion at 3–6 and 7–12 months, respectively. pCONUS offers a safe and reasonably effective treatment of WNBAs, demonstrated by acceptable adequate aneurysm occlusion and low rates of adverse neurologic events. |
format | Online Article Text |
id | pubmed-8836830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88368302022-02-12 Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms Aguilar Pérez, Marta Henkes, Hans Kurre, Wiebke Bleise, Carlos Lylyk, Pedro Nicolás Lundquist, Javier Turjman, Francis Alhazmi, Hanan Loehr, Christian Felber, Stephan Deutschmann, Hannes Lowens, Stephan Delehaye, Luigi Möhlenbruch, Markus Hattingen, Jörg Lylyk, Pedro J Clin Med Article Coil embolization has become a well-established option for the treatment of intracranial aneurysms. Yet, wide-neck bifurcation aneurysms (WNBAs) remain a challenge. The pCONUS is the first generation of a stent-like implant for the bridging of WNBAs to enable coiling. The pToWin study was a prospective, single-arm, multicenter study conducted to analyze the safety and efficacy of the pCONUS in the treatment of WNBAs. The primary effectiveness endpoint was the rate of adequate occlusion of the aneurysm at 3–6 and 7–12 months. The primary safety endpoint was the occurrence of major ipsilateral stroke or neurological death during the follow-up. A total of 115 patients were included. Aneurysm locations were the middle cerebral artery in 52 (45.2%), the anterior communicating artery in 35 (30.4%), the basilar artery in 23 (20%), the internal carotid artery terminus in three (2.6%), and the pericallosal artery in two (1.7%) patients. Treatment was successfully performed in all but one patient. The morbi-mortality rate was 1.9% and 2.3% at 3–6 and 7–12 months, respectively. Of the aneurysms, 75.0% and 65.6% showed adequate occlusion at 3–6 and 7–12 months, respectively. pCONUS offers a safe and reasonably effective treatment of WNBAs, demonstrated by acceptable adequate aneurysm occlusion and low rates of adverse neurologic events. MDPI 2022-02-08 /pmc/articles/PMC8836830/ /pubmed/35160333 http://dx.doi.org/10.3390/jcm11030884 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aguilar Pérez, Marta Henkes, Hans Kurre, Wiebke Bleise, Carlos Lylyk, Pedro Nicolás Lundquist, Javier Turjman, Francis Alhazmi, Hanan Loehr, Christian Felber, Stephan Deutschmann, Hannes Lowens, Stephan Delehaye, Luigi Möhlenbruch, Markus Hattingen, Jörg Lylyk, Pedro Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms |
title | Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms |
title_full | Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms |
title_fullStr | Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms |
title_full_unstemmed | Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms |
title_short | Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms |
title_sort | results of the ptowin study: using the pconus device for the treatment of wide-neck intracranial aneurysms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836830/ https://www.ncbi.nlm.nih.gov/pubmed/35160333 http://dx.doi.org/10.3390/jcm11030884 |
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