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Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis
Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due to alterations caused by chronic liver failure. In the past two years, since the COVID-19 pandemic started, several studies have described the affinity of SARS-CoV-2 with the liver and biliary...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836842/ https://www.ncbi.nlm.nih.gov/pubmed/35160114 http://dx.doi.org/10.3390/jcm11030652 |
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author | Cerbu, Bianca Grigoras, Mirela Loredana Bratosin, Felix Bogdan, Iulia Citu, Cosmin Bota, Adrian Vasile Timircan, Madalina Bratu, Melania Lavinia Levai, Mihaela Codrina Marincu, Iosif |
author_facet | Cerbu, Bianca Grigoras, Mirela Loredana Bratosin, Felix Bogdan, Iulia Citu, Cosmin Bota, Adrian Vasile Timircan, Madalina Bratu, Melania Lavinia Levai, Mihaela Codrina Marincu, Iosif |
author_sort | Cerbu, Bianca |
collection | PubMed |
description | Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due to alterations caused by chronic liver failure. In the past two years, since the COVID-19 pandemic started, several studies have described the affinity of SARS-CoV-2 with the liver and biliary cells. Considering hepatitis C as a significant independent factor for cirrhosis in Romania, this research was built on the premises that this certain group of patients is susceptible to alterations of their serum parameters that are yet to be described, which might be useful in the management of COVID-19 in these individuals. A retrospective cohort study was developed at a tertiary hospital for infectious disease in Romania, which included a total of 242 patients with hepatitis C cirrhosis across two years, out of which 46 patients were infected with SARS-CoV-2. Stratification by patient weight and COVID-19 status identified several important laboratory serum tests as predictors for acute-on-chronic liver failure and risk for intensive care unit admission. Thus, white blood cell count, lymphocyte count, ferritin, hypoglycemia, prothrombin time, and HCV viral load were independent risk factors for ACLF in patients with COVID-19. High PT, creatinine, BUN, and HCV viral load were the strongest predictors for ICU admission. Inflammatory markers and parameters of gas exchange were also observed as risk factors for ACLF and ICU admission, including procalcitonin, CRP, IL-6, and D-dimers. Our study questions and confirms the health impact of COVID-19 on patients with cirrhosis and whether their laboratory profile significantly changes due to SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8836842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88368422022-02-12 Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis Cerbu, Bianca Grigoras, Mirela Loredana Bratosin, Felix Bogdan, Iulia Citu, Cosmin Bota, Adrian Vasile Timircan, Madalina Bratu, Melania Lavinia Levai, Mihaela Codrina Marincu, Iosif J Clin Med Article Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due to alterations caused by chronic liver failure. In the past two years, since the COVID-19 pandemic started, several studies have described the affinity of SARS-CoV-2 with the liver and biliary cells. Considering hepatitis C as a significant independent factor for cirrhosis in Romania, this research was built on the premises that this certain group of patients is susceptible to alterations of their serum parameters that are yet to be described, which might be useful in the management of COVID-19 in these individuals. A retrospective cohort study was developed at a tertiary hospital for infectious disease in Romania, which included a total of 242 patients with hepatitis C cirrhosis across two years, out of which 46 patients were infected with SARS-CoV-2. Stratification by patient weight and COVID-19 status identified several important laboratory serum tests as predictors for acute-on-chronic liver failure and risk for intensive care unit admission. Thus, white blood cell count, lymphocyte count, ferritin, hypoglycemia, prothrombin time, and HCV viral load were independent risk factors for ACLF in patients with COVID-19. High PT, creatinine, BUN, and HCV viral load were the strongest predictors for ICU admission. Inflammatory markers and parameters of gas exchange were also observed as risk factors for ACLF and ICU admission, including procalcitonin, CRP, IL-6, and D-dimers. Our study questions and confirms the health impact of COVID-19 on patients with cirrhosis and whether their laboratory profile significantly changes due to SARS-CoV-2 infection. MDPI 2022-01-27 /pmc/articles/PMC8836842/ /pubmed/35160114 http://dx.doi.org/10.3390/jcm11030652 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cerbu, Bianca Grigoras, Mirela Loredana Bratosin, Felix Bogdan, Iulia Citu, Cosmin Bota, Adrian Vasile Timircan, Madalina Bratu, Melania Lavinia Levai, Mihaela Codrina Marincu, Iosif Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis |
title | Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis |
title_full | Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis |
title_fullStr | Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis |
title_full_unstemmed | Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis |
title_short | Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis |
title_sort | laboratory profile of covid-19 patients with hepatitis c-related liver cirrhosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836842/ https://www.ncbi.nlm.nih.gov/pubmed/35160114 http://dx.doi.org/10.3390/jcm11030652 |
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