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Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study

Background: Cardiovascular diseases (CVD) are still the leading cause of death in developed countries. The aim of this study was to calculate the potential for CV risk reduction when using three different prevention strategies to evaluate the effect of primary prevention. Methods: A total of 931 ind...

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Autores principales: Chlabicz, Małgorzata, Jamiołkowski, Jacek, Łaguna, Wojciech, Dubatówka, Marlena, Sowa, Paweł, Łapińska, Magda, Szpakowicz, Anna, Zieleniewska, Natalia, Zalewska, Magdalena, Raczkowski, Andrzej, Kamiński, Karol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836845/
https://www.ncbi.nlm.nih.gov/pubmed/35160138
http://dx.doi.org/10.3390/jcm11030688
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author Chlabicz, Małgorzata
Jamiołkowski, Jacek
Łaguna, Wojciech
Dubatówka, Marlena
Sowa, Paweł
Łapińska, Magda
Szpakowicz, Anna
Zieleniewska, Natalia
Zalewska, Magdalena
Raczkowski, Andrzej
Kamiński, Karol A.
author_facet Chlabicz, Małgorzata
Jamiołkowski, Jacek
Łaguna, Wojciech
Dubatówka, Marlena
Sowa, Paweł
Łapińska, Magda
Szpakowicz, Anna
Zieleniewska, Natalia
Zalewska, Magdalena
Raczkowski, Andrzej
Kamiński, Karol A.
author_sort Chlabicz, Małgorzata
collection PubMed
description Background: Cardiovascular diseases (CVD) are still the leading cause of death in developed countries. The aim of this study was to calculate the potential for CV risk reduction when using three different prevention strategies to evaluate the effect of primary prevention. Methods: A total of 931 individuals aged 20–79 years old from the Bialystok PLUS Study were analyzed. The study population was divided into CV risk classes. The Systematic Coronary Risk Estimation (SCORE), Framingham Risk Score (FRS), and LIFE-CVD were used to assess CV risk. The optimal prevention strategy assumed the attainment of therapeutic goals according to the European guidelines. The moderate strategy assumed therapeutic goals in participants with increased risk factors: a reduction in systolic blood pressure by 10 mmHg when it was above 140 mmHg, a reduction in total cholesterol by 25% when it was above 190 mg/dL, and a reduction in body mass index below 30. The minimal prevention strategy assumed that CV risk would be lowered by lifestyle modifications. The greatest CV risk reduction was achieved in the optimal model and then in the minimal model, and the lowest risk reduction was achieved in the moderate model, e.g., using the optimal model of prevention (Model 1). In the total population, we achieved a reduction of −1.74% in the 10-year risk of CVD death (SCORE) in relation to the baseline model, a −0.85% reduction when using the moderate prevention model (Model 2), and a −1.11% reduction when using the minimal prevention model (Model 3). However, in the low CV risk class, the best model was the minimal one (risk reduction of −0.72%), which showed even better results than the optimal one (reduction of −0.69%) using the FRS. Conclusion: A strategy based on lifestyle modifications in a population without established CVD could be more effective than the moderate strategy used in the present study. Moreover, applying a minimal strategy to the low CV risk class population may even be beneficial for an optimal model.
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spelling pubmed-88368452022-02-12 Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study Chlabicz, Małgorzata Jamiołkowski, Jacek Łaguna, Wojciech Dubatówka, Marlena Sowa, Paweł Łapińska, Magda Szpakowicz, Anna Zieleniewska, Natalia Zalewska, Magdalena Raczkowski, Andrzej Kamiński, Karol A. J Clin Med Article Background: Cardiovascular diseases (CVD) are still the leading cause of death in developed countries. The aim of this study was to calculate the potential for CV risk reduction when using three different prevention strategies to evaluate the effect of primary prevention. Methods: A total of 931 individuals aged 20–79 years old from the Bialystok PLUS Study were analyzed. The study population was divided into CV risk classes. The Systematic Coronary Risk Estimation (SCORE), Framingham Risk Score (FRS), and LIFE-CVD were used to assess CV risk. The optimal prevention strategy assumed the attainment of therapeutic goals according to the European guidelines. The moderate strategy assumed therapeutic goals in participants with increased risk factors: a reduction in systolic blood pressure by 10 mmHg when it was above 140 mmHg, a reduction in total cholesterol by 25% when it was above 190 mg/dL, and a reduction in body mass index below 30. The minimal prevention strategy assumed that CV risk would be lowered by lifestyle modifications. The greatest CV risk reduction was achieved in the optimal model and then in the minimal model, and the lowest risk reduction was achieved in the moderate model, e.g., using the optimal model of prevention (Model 1). In the total population, we achieved a reduction of −1.74% in the 10-year risk of CVD death (SCORE) in relation to the baseline model, a −0.85% reduction when using the moderate prevention model (Model 2), and a −1.11% reduction when using the minimal prevention model (Model 3). However, in the low CV risk class, the best model was the minimal one (risk reduction of −0.72%), which showed even better results than the optimal one (reduction of −0.69%) using the FRS. Conclusion: A strategy based on lifestyle modifications in a population without established CVD could be more effective than the moderate strategy used in the present study. Moreover, applying a minimal strategy to the low CV risk class population may even be beneficial for an optimal model. MDPI 2022-01-28 /pmc/articles/PMC8836845/ /pubmed/35160138 http://dx.doi.org/10.3390/jcm11030688 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chlabicz, Małgorzata
Jamiołkowski, Jacek
Łaguna, Wojciech
Dubatówka, Marlena
Sowa, Paweł
Łapińska, Magda
Szpakowicz, Anna
Zieleniewska, Natalia
Zalewska, Magdalena
Raczkowski, Andrzej
Kamiński, Karol A.
Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study
title Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study
title_full Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study
title_fullStr Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study
title_full_unstemmed Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study
title_short Effectiveness of Lifestyle Modification vs. Therapeutic, Preventative Strategies for Reducing Cardiovascular Risk in Primary Prevention—A Cohort Study
title_sort effectiveness of lifestyle modification vs. therapeutic, preventative strategies for reducing cardiovascular risk in primary prevention—a cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836845/
https://www.ncbi.nlm.nih.gov/pubmed/35160138
http://dx.doi.org/10.3390/jcm11030688
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