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Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
Background: fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development. Methods: we pe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836883/ https://www.ncbi.nlm.nih.gov/pubmed/35160214 http://dx.doi.org/10.3390/jcm11030763 |
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author | Khoury, Tawfik Sbeit, Wisam |
author_facet | Khoury, Tawfik Sbeit, Wisam |
author_sort | Khoury, Tawfik |
collection | PubMed |
description | Background: fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development. Methods: we performed a retrospective cross-sectional study including all patients who underwent endoscopic ultrasound (EUS) for hepatobiliary indications. The study cohort was divided into patients with and without PC. Univariate and multivariate analysis were used to assess the association of several parameters with PC. Results: overall, 519 patients were included in the study. Of them, 48 had PC (PC group), and 471 did not (non-PC group). In univariate analysis, age (OR 1.04, 95% CI 1.01–1.07, p = 0.004), congestive heart failure (CHF) (OR 3.89, 95% CI 1.72–8.79, p = 0.001), ischemic heart disease (IHD) (OR 3.36, 95% CI 1.59–7.05, p = 0.001), hypertension (OR 2.42, 95% CI 1.33–4.41, p = 0.004) and fatty pancreas (FP) (OR 2.62, 95% CI 1.23–5.57, p = 0.01) were significantly associated with PC. In multivariate logistic regression analysis, only FP kept its association (OR 2.35, 95% CI 1.04–5.33, p = 0.04). Conclusion: FP was significantly associated with PC. A follow-up plan should be considered for individuals with FP. |
format | Online Article Text |
id | pubmed-8836883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88368832022-02-12 Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? Khoury, Tawfik Sbeit, Wisam J Clin Med Article Background: fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development. Methods: we performed a retrospective cross-sectional study including all patients who underwent endoscopic ultrasound (EUS) for hepatobiliary indications. The study cohort was divided into patients with and without PC. Univariate and multivariate analysis were used to assess the association of several parameters with PC. Results: overall, 519 patients were included in the study. Of them, 48 had PC (PC group), and 471 did not (non-PC group). In univariate analysis, age (OR 1.04, 95% CI 1.01–1.07, p = 0.004), congestive heart failure (CHF) (OR 3.89, 95% CI 1.72–8.79, p = 0.001), ischemic heart disease (IHD) (OR 3.36, 95% CI 1.59–7.05, p = 0.001), hypertension (OR 2.42, 95% CI 1.33–4.41, p = 0.004) and fatty pancreas (FP) (OR 2.62, 95% CI 1.23–5.57, p = 0.01) were significantly associated with PC. In multivariate logistic regression analysis, only FP kept its association (OR 2.35, 95% CI 1.04–5.33, p = 0.04). Conclusion: FP was significantly associated with PC. A follow-up plan should be considered for individuals with FP. MDPI 2022-01-30 /pmc/articles/PMC8836883/ /pubmed/35160214 http://dx.doi.org/10.3390/jcm11030763 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khoury, Tawfik Sbeit, Wisam Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? |
title | Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? |
title_full | Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? |
title_fullStr | Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? |
title_full_unstemmed | Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? |
title_short | Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? |
title_sort | fatty pancreas and pancreatic cancer: an overlooked association? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836883/ https://www.ncbi.nlm.nih.gov/pubmed/35160214 http://dx.doi.org/10.3390/jcm11030763 |
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