Cargando…

Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?

Background: fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development. Methods: we pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Khoury, Tawfik, Sbeit, Wisam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836883/
https://www.ncbi.nlm.nih.gov/pubmed/35160214
http://dx.doi.org/10.3390/jcm11030763
_version_ 1784649787192115200
author Khoury, Tawfik
Sbeit, Wisam
author_facet Khoury, Tawfik
Sbeit, Wisam
author_sort Khoury, Tawfik
collection PubMed
description Background: fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development. Methods: we performed a retrospective cross-sectional study including all patients who underwent endoscopic ultrasound (EUS) for hepatobiliary indications. The study cohort was divided into patients with and without PC. Univariate and multivariate analysis were used to assess the association of several parameters with PC. Results: overall, 519 patients were included in the study. Of them, 48 had PC (PC group), and 471 did not (non-PC group). In univariate analysis, age (OR 1.04, 95% CI 1.01–1.07, p = 0.004), congestive heart failure (CHF) (OR 3.89, 95% CI 1.72–8.79, p = 0.001), ischemic heart disease (IHD) (OR 3.36, 95% CI 1.59–7.05, p = 0.001), hypertension (OR 2.42, 95% CI 1.33–4.41, p = 0.004) and fatty pancreas (FP) (OR 2.62, 95% CI 1.23–5.57, p = 0.01) were significantly associated with PC. In multivariate logistic regression analysis, only FP kept its association (OR 2.35, 95% CI 1.04–5.33, p = 0.04). Conclusion: FP was significantly associated with PC. A follow-up plan should be considered for individuals with FP.
format Online
Article
Text
id pubmed-8836883
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88368832022-02-12 Fatty Pancreas and Pancreatic Cancer: An Overlooked Association? Khoury, Tawfik Sbeit, Wisam J Clin Med Article Background: fatty pancreas (FP) is an old observation, but a new disease with clinical implications and several associated comorbid conditions, ranging from mild to life-threatening diseases. Herein, we aimed to assess the association between FP and pancreatic cancer (PC) development. Methods: we performed a retrospective cross-sectional study including all patients who underwent endoscopic ultrasound (EUS) for hepatobiliary indications. The study cohort was divided into patients with and without PC. Univariate and multivariate analysis were used to assess the association of several parameters with PC. Results: overall, 519 patients were included in the study. Of them, 48 had PC (PC group), and 471 did not (non-PC group). In univariate analysis, age (OR 1.04, 95% CI 1.01–1.07, p = 0.004), congestive heart failure (CHF) (OR 3.89, 95% CI 1.72–8.79, p = 0.001), ischemic heart disease (IHD) (OR 3.36, 95% CI 1.59–7.05, p = 0.001), hypertension (OR 2.42, 95% CI 1.33–4.41, p = 0.004) and fatty pancreas (FP) (OR 2.62, 95% CI 1.23–5.57, p = 0.01) were significantly associated with PC. In multivariate logistic regression analysis, only FP kept its association (OR 2.35, 95% CI 1.04–5.33, p = 0.04). Conclusion: FP was significantly associated with PC. A follow-up plan should be considered for individuals with FP. MDPI 2022-01-30 /pmc/articles/PMC8836883/ /pubmed/35160214 http://dx.doi.org/10.3390/jcm11030763 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khoury, Tawfik
Sbeit, Wisam
Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
title Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
title_full Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
title_fullStr Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
title_full_unstemmed Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
title_short Fatty Pancreas and Pancreatic Cancer: An Overlooked Association?
title_sort fatty pancreas and pancreatic cancer: an overlooked association?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836883/
https://www.ncbi.nlm.nih.gov/pubmed/35160214
http://dx.doi.org/10.3390/jcm11030763
work_keys_str_mv AT khourytawfik fattypancreasandpancreaticcanceranoverlookedassociation
AT sbeitwisam fattypancreasandpancreaticcanceranoverlookedassociation