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Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study
Background: We analyzed data from COVID-19 patients in Japan to assess the utility of the 4C mortality score as compared with conventional scorings. Methods: In this multicenter study, COVID-19 patients hospitalized between March 2020 and June 2021, over 16 years old, were recruited. The superiority...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836893/ https://www.ncbi.nlm.nih.gov/pubmed/35160272 http://dx.doi.org/10.3390/jcm11030821 |
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author | Ocho, Kazuki Hagiya, Hideharu Hasegawa, Kou Fujita, Kouji Otsuka, Fumio |
author_facet | Ocho, Kazuki Hagiya, Hideharu Hasegawa, Kou Fujita, Kouji Otsuka, Fumio |
author_sort | Ocho, Kazuki |
collection | PubMed |
description | Background: We analyzed data from COVID-19 patients in Japan to assess the utility of the 4C mortality score as compared with conventional scorings. Methods: In this multicenter study, COVID-19 patients hospitalized between March 2020 and June 2021, over 16 years old, were recruited. The superiority for correctly predicting mortality and severity by applying the receiver operating characteristic (ROC) curve was compared. A Cox regression model was used to compare the length of hospitalization for each risk group of 4C mortality score. Results: Among 206 patients, 21 patients died. The area under the curve (AUC) (95% confidential interval (CI)) of the ROC curve for mortality and severity, respectively, of 4C mortality scores (0.84 (95% CI 0.76–0.92) and 0.85 (95% CI 0.80–0.91)) were higher than those of qSOFA (0.66 (95% CI 0.53–0.78) and 0.67 (95% CI 0.59–0.75)), SOFA (0.70 (95% CI 0.55–0.84) and 0.81 (95% CI 0.74–0.89)), A-DROP (0.78 (95% CI 0.69–0.88) and 0.81 (95% CI 0.74–0.88)), and CURB-65 (0.82 (95% CI 0.74–0.90) and 0.82 (95% CI 0.76–0.88)). For length of hospitalization among survivors, the intermediate- and high- or very high-risk groups had significantly lower hazard ratios, i.e., 0.48 (95% CI 0.30–0.76)) and 0.23 (95% CI 0.13–0.43) for discharge. Conclusions: The 4C mortality score is better for estimating mortality and severity in COVID-19 Japanese patients than other scoring systems. |
format | Online Article Text |
id | pubmed-8836893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88368932022-02-12 Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study Ocho, Kazuki Hagiya, Hideharu Hasegawa, Kou Fujita, Kouji Otsuka, Fumio J Clin Med Article Background: We analyzed data from COVID-19 patients in Japan to assess the utility of the 4C mortality score as compared with conventional scorings. Methods: In this multicenter study, COVID-19 patients hospitalized between March 2020 and June 2021, over 16 years old, were recruited. The superiority for correctly predicting mortality and severity by applying the receiver operating characteristic (ROC) curve was compared. A Cox regression model was used to compare the length of hospitalization for each risk group of 4C mortality score. Results: Among 206 patients, 21 patients died. The area under the curve (AUC) (95% confidential interval (CI)) of the ROC curve for mortality and severity, respectively, of 4C mortality scores (0.84 (95% CI 0.76–0.92) and 0.85 (95% CI 0.80–0.91)) were higher than those of qSOFA (0.66 (95% CI 0.53–0.78) and 0.67 (95% CI 0.59–0.75)), SOFA (0.70 (95% CI 0.55–0.84) and 0.81 (95% CI 0.74–0.89)), A-DROP (0.78 (95% CI 0.69–0.88) and 0.81 (95% CI 0.74–0.88)), and CURB-65 (0.82 (95% CI 0.74–0.90) and 0.82 (95% CI 0.76–0.88)). For length of hospitalization among survivors, the intermediate- and high- or very high-risk groups had significantly lower hazard ratios, i.e., 0.48 (95% CI 0.30–0.76)) and 0.23 (95% CI 0.13–0.43) for discharge. Conclusions: The 4C mortality score is better for estimating mortality and severity in COVID-19 Japanese patients than other scoring systems. MDPI 2022-02-03 /pmc/articles/PMC8836893/ /pubmed/35160272 http://dx.doi.org/10.3390/jcm11030821 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ocho, Kazuki Hagiya, Hideharu Hasegawa, Kou Fujita, Kouji Otsuka, Fumio Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study |
title | Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study |
title_full | Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study |
title_fullStr | Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study |
title_full_unstemmed | Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study |
title_short | Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study |
title_sort | clinical utility of 4c mortality scores among japanese covid-19 patients: a multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836893/ https://www.ncbi.nlm.nih.gov/pubmed/35160272 http://dx.doi.org/10.3390/jcm11030821 |
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