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Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin
The importance of early evaluation by a neurotologist in patients with infective endocarditis treated with systemic gentamicin and its impact on the patients’ quality of life was evaluated. This is a longitudinal retrospective cohort study of 29 patients who received intravenous gentamicin for the t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836904/ https://www.ncbi.nlm.nih.gov/pubmed/35160038 http://dx.doi.org/10.3390/jcm11030586 |
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author | Ferreira-Cendon, Sofía Martinez-Carranza, Ramon Fernandez-Nava, Maria José Villaoslada-Fuente, Rosana Sanchez-Gomez, Hortensia Santa Cruz-Ruiz, Santiago Sanchez-Ledesma, María Batuecas-Caletrio, Angel |
author_facet | Ferreira-Cendon, Sofía Martinez-Carranza, Ramon Fernandez-Nava, Maria José Villaoslada-Fuente, Rosana Sanchez-Gomez, Hortensia Santa Cruz-Ruiz, Santiago Sanchez-Ledesma, María Batuecas-Caletrio, Angel |
author_sort | Ferreira-Cendon, Sofía |
collection | PubMed |
description | The importance of early evaluation by a neurotologist in patients with infective endocarditis treated with systemic gentamicin and its impact on the patients’ quality of life was evaluated. This is a longitudinal retrospective cohort study of 29 patients who received intravenous gentamicin for the treatment of infective endocarditis. Patients were classified into two groups: group A, before a neurotologist was included in the treatment protocol, and group B, after the inclusion of a neurotologist. The frequency of the different symptoms in each group was measured, and the gain of the vestibulo-ocular reflex (VOR) and its relationship with the presence of oscillopsia. In total, 13 and 16 patients were assigned to groups A and B, respectively. The mean gain of the VOR measured using the video head impulse test in group A was 0.44 in the best side and 0.39 in the worst side. In group B, the mean gain was 0.71 (best side) and 0.64 (worst side) (p < 0.0001). The patients who complained about oscillopsia had a main gain of 0.41 in the best side and 0.35 in the worst side. Evaluation of vestibular function should be included in the infective endocarditis treatment protocol, including the adverse effects of systemic gentamicin. |
format | Online Article Text |
id | pubmed-8836904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88369042022-02-12 Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin Ferreira-Cendon, Sofía Martinez-Carranza, Ramon Fernandez-Nava, Maria José Villaoslada-Fuente, Rosana Sanchez-Gomez, Hortensia Santa Cruz-Ruiz, Santiago Sanchez-Ledesma, María Batuecas-Caletrio, Angel J Clin Med Article The importance of early evaluation by a neurotologist in patients with infective endocarditis treated with systemic gentamicin and its impact on the patients’ quality of life was evaluated. This is a longitudinal retrospective cohort study of 29 patients who received intravenous gentamicin for the treatment of infective endocarditis. Patients were classified into two groups: group A, before a neurotologist was included in the treatment protocol, and group B, after the inclusion of a neurotologist. The frequency of the different symptoms in each group was measured, and the gain of the vestibulo-ocular reflex (VOR) and its relationship with the presence of oscillopsia. In total, 13 and 16 patients were assigned to groups A and B, respectively. The mean gain of the VOR measured using the video head impulse test in group A was 0.44 in the best side and 0.39 in the worst side. In group B, the mean gain was 0.71 (best side) and 0.64 (worst side) (p < 0.0001). The patients who complained about oscillopsia had a main gain of 0.41 in the best side and 0.35 in the worst side. Evaluation of vestibular function should be included in the infective endocarditis treatment protocol, including the adverse effects of systemic gentamicin. MDPI 2022-01-25 /pmc/articles/PMC8836904/ /pubmed/35160038 http://dx.doi.org/10.3390/jcm11030586 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ferreira-Cendon, Sofía Martinez-Carranza, Ramon Fernandez-Nava, Maria José Villaoslada-Fuente, Rosana Sanchez-Gomez, Hortensia Santa Cruz-Ruiz, Santiago Sanchez-Ledesma, María Batuecas-Caletrio, Angel Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin |
title | Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin |
title_full | Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin |
title_fullStr | Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin |
title_full_unstemmed | Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin |
title_short | Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin |
title_sort | prevention of severe vestibular hypofunction after systemic gentamicin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836904/ https://www.ncbi.nlm.nih.gov/pubmed/35160038 http://dx.doi.org/10.3390/jcm11030586 |
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