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Calcium Signalling in Breast Cancer Associated Bone Pain

Calcium (Ca(2+)) is involved as a signalling mediator in a broad variety of physiological processes. Some of the fastest responses in human body like neuronal action potential firing, to the slowest gene transcriptional regulation processes are controlled by pathways involving calcium signalling. Un...

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Autores principales: Bortolin, Andrea, Neto, Estrela, Lamghari, Meriem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836937/
https://www.ncbi.nlm.nih.gov/pubmed/35163823
http://dx.doi.org/10.3390/ijms23031902
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author Bortolin, Andrea
Neto, Estrela
Lamghari, Meriem
author_facet Bortolin, Andrea
Neto, Estrela
Lamghari, Meriem
author_sort Bortolin, Andrea
collection PubMed
description Calcium (Ca(2+)) is involved as a signalling mediator in a broad variety of physiological processes. Some of the fastest responses in human body like neuronal action potential firing, to the slowest gene transcriptional regulation processes are controlled by pathways involving calcium signalling. Under pathological conditions these mechanisms are also involved in tumoral cells reprogramming, resulting in the altered expression of genes associated with cell proliferation, metastatisation and homing to the secondary metastatic site. On the other hand, calcium exerts a central function in nociception, from cues sensing in distal neurons, to signal modulation and interpretation in the central nervous system leading, in pathological conditions, to hyperalgesia, allodynia and pain chronicization. It is well known the relationship between cancer and pain when tumoral metastatic cells settle in the bones, especially in late breast cancer stage, where they alter the bone micro-environment leading to bone lesions and resulting in pain refractory to the conventional analgesic therapies. The purpose of this review is to address the Ca(2+) signalling mechanisms involved in cancer cell metastatisation as well as the function of the same signalling tools in pain regulation and transmission. Finally, the possible interactions between these two cells types cohabiting the same Ca(2+) rich environment will be further explored attempting to highlight new possible therapeutical targets.
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spelling pubmed-88369372022-02-12 Calcium Signalling in Breast Cancer Associated Bone Pain Bortolin, Andrea Neto, Estrela Lamghari, Meriem Int J Mol Sci Review Calcium (Ca(2+)) is involved as a signalling mediator in a broad variety of physiological processes. Some of the fastest responses in human body like neuronal action potential firing, to the slowest gene transcriptional regulation processes are controlled by pathways involving calcium signalling. Under pathological conditions these mechanisms are also involved in tumoral cells reprogramming, resulting in the altered expression of genes associated with cell proliferation, metastatisation and homing to the secondary metastatic site. On the other hand, calcium exerts a central function in nociception, from cues sensing in distal neurons, to signal modulation and interpretation in the central nervous system leading, in pathological conditions, to hyperalgesia, allodynia and pain chronicization. It is well known the relationship between cancer and pain when tumoral metastatic cells settle in the bones, especially in late breast cancer stage, where they alter the bone micro-environment leading to bone lesions and resulting in pain refractory to the conventional analgesic therapies. The purpose of this review is to address the Ca(2+) signalling mechanisms involved in cancer cell metastatisation as well as the function of the same signalling tools in pain regulation and transmission. Finally, the possible interactions between these two cells types cohabiting the same Ca(2+) rich environment will be further explored attempting to highlight new possible therapeutical targets. MDPI 2022-02-08 /pmc/articles/PMC8836937/ /pubmed/35163823 http://dx.doi.org/10.3390/ijms23031902 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bortolin, Andrea
Neto, Estrela
Lamghari, Meriem
Calcium Signalling in Breast Cancer Associated Bone Pain
title Calcium Signalling in Breast Cancer Associated Bone Pain
title_full Calcium Signalling in Breast Cancer Associated Bone Pain
title_fullStr Calcium Signalling in Breast Cancer Associated Bone Pain
title_full_unstemmed Calcium Signalling in Breast Cancer Associated Bone Pain
title_short Calcium Signalling in Breast Cancer Associated Bone Pain
title_sort calcium signalling in breast cancer associated bone pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836937/
https://www.ncbi.nlm.nih.gov/pubmed/35163823
http://dx.doi.org/10.3390/ijms23031902
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