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Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction

Background: Right ventricular (RV) to pulmonary circulation (PC) coupling can stratify prognosis in heart failure (HF). In this study, we assessed the prognostic role of the mean velocity of the pulmonary artery (mvPA) determined by cardiac magnetic resonance (CMR) in HF with preserved ejection frac...

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Autores principales: Trejo-Velasco, Blanca, Cruz-González, Ignacio, Barreiro-Pérez, Manuel, Díaz-Peláez, Elena, García-González, Pilar, Martín-García, Ana, Eiros, Rocío, Merchán-Gómez, Soraya, Pérez del Villar, Candelas, Fabregat-Andrés, Oscar, Ridocci-Soriano, Francisco, Sánchez, Pedro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836987/
https://www.ncbi.nlm.nih.gov/pubmed/35159943
http://dx.doi.org/10.3390/jcm11030491
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author Trejo-Velasco, Blanca
Cruz-González, Ignacio
Barreiro-Pérez, Manuel
Díaz-Peláez, Elena
García-González, Pilar
Martín-García, Ana
Eiros, Rocío
Merchán-Gómez, Soraya
Pérez del Villar, Candelas
Fabregat-Andrés, Oscar
Ridocci-Soriano, Francisco
Sánchez, Pedro L.
author_facet Trejo-Velasco, Blanca
Cruz-González, Ignacio
Barreiro-Pérez, Manuel
Díaz-Peláez, Elena
García-González, Pilar
Martín-García, Ana
Eiros, Rocío
Merchán-Gómez, Soraya
Pérez del Villar, Candelas
Fabregat-Andrés, Oscar
Ridocci-Soriano, Francisco
Sánchez, Pedro L.
author_sort Trejo-Velasco, Blanca
collection PubMed
description Background: Right ventricular (RV) to pulmonary circulation (PC) coupling can stratify prognosis in heart failure (HF). In this study, we assessed the prognostic role of the mean velocity of the pulmonary artery (mvPA) determined by cardiac magnetic resonance (CMR) in HF with preserved ejection fraction (HFpEF). Methods: Inclusion of 58 HFpEF outpatients that underwent CMR with measurement of RV–PC coupling parameters including mvPA between 2016 and 2019. The primary combined endpoint was a composite of HF readmissions and all-cause mortality. Results: Optimal cut-off value of mvPA calculated by receiver operating curve for the prediction of the primary endpoint was 9 cm/s. Over a median follow-up of 23 months (interquartile range: 24), 21 patients met the primary endpoint. The primary endpoint was more frequent in patients with mvPA ≤ 9 cm/s, as indicated by Kaplan–Meier survival curves; Log-Rank: 9.193, p = 0.02, regardless of RV dysfunction. On Cox multivariate analysis, mvPA ≤ 9 cm/s emerged as an independent prognostic predictor of the primary endpoint (HR: 4.11, 95% CI: 1.28–13.19, p = 0.017), together with left atrial area by CMR (HR: 1.08, 95% CI: 1.01–1.24, p = 0.034). Conclusions: In our HFpEF cohort, mvPA was associated with a higher rate of the primary endpoint, regardless of RV function, thus enabling identification of patients at higher risk of cardiovascular events before structural damage onset.
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spelling pubmed-88369872022-02-12 Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction Trejo-Velasco, Blanca Cruz-González, Ignacio Barreiro-Pérez, Manuel Díaz-Peláez, Elena García-González, Pilar Martín-García, Ana Eiros, Rocío Merchán-Gómez, Soraya Pérez del Villar, Candelas Fabregat-Andrés, Oscar Ridocci-Soriano, Francisco Sánchez, Pedro L. J Clin Med Article Background: Right ventricular (RV) to pulmonary circulation (PC) coupling can stratify prognosis in heart failure (HF). In this study, we assessed the prognostic role of the mean velocity of the pulmonary artery (mvPA) determined by cardiac magnetic resonance (CMR) in HF with preserved ejection fraction (HFpEF). Methods: Inclusion of 58 HFpEF outpatients that underwent CMR with measurement of RV–PC coupling parameters including mvPA between 2016 and 2019. The primary combined endpoint was a composite of HF readmissions and all-cause mortality. Results: Optimal cut-off value of mvPA calculated by receiver operating curve for the prediction of the primary endpoint was 9 cm/s. Over a median follow-up of 23 months (interquartile range: 24), 21 patients met the primary endpoint. The primary endpoint was more frequent in patients with mvPA ≤ 9 cm/s, as indicated by Kaplan–Meier survival curves; Log-Rank: 9.193, p = 0.02, regardless of RV dysfunction. On Cox multivariate analysis, mvPA ≤ 9 cm/s emerged as an independent prognostic predictor of the primary endpoint (HR: 4.11, 95% CI: 1.28–13.19, p = 0.017), together with left atrial area by CMR (HR: 1.08, 95% CI: 1.01–1.24, p = 0.034). Conclusions: In our HFpEF cohort, mvPA was associated with a higher rate of the primary endpoint, regardless of RV function, thus enabling identification of patients at higher risk of cardiovascular events before structural damage onset. MDPI 2022-01-19 /pmc/articles/PMC8836987/ /pubmed/35159943 http://dx.doi.org/10.3390/jcm11030491 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trejo-Velasco, Blanca
Cruz-González, Ignacio
Barreiro-Pérez, Manuel
Díaz-Peláez, Elena
García-González, Pilar
Martín-García, Ana
Eiros, Rocío
Merchán-Gómez, Soraya
Pérez del Villar, Candelas
Fabregat-Andrés, Oscar
Ridocci-Soriano, Francisco
Sánchez, Pedro L.
Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction
title Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction
title_full Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction
title_fullStr Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction
title_full_unstemmed Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction
title_short Mean Velocity of the Pulmonary Artery as a Clinically Relevant Prognostic Indicator in Patients with Heart Failure with Preserved Ejection Fraction
title_sort mean velocity of the pulmonary artery as a clinically relevant prognostic indicator in patients with heart failure with preserved ejection fraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836987/
https://www.ncbi.nlm.nih.gov/pubmed/35159943
http://dx.doi.org/10.3390/jcm11030491
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