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Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study

The disorders of gut–brain interaction (DGBI) have been associated with Fibromyalgia (FM). However, there are no data about the relationship between FM and DGBI using Rome IV criteria. This study aimed to evaluate the prevalence of FM in patients with Irritable Bowel Syndrome (IBS) and/or Functional...

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Autores principales: Settembre, Carmela, D’Antonio, Elvira, Moscato, Paolo, Loi, Gabriella, Santonicola, Antonella, Iovino, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836992/
https://www.ncbi.nlm.nih.gov/pubmed/35160260
http://dx.doi.org/10.3390/jcm11030809
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author Settembre, Carmela
D’Antonio, Elvira
Moscato, Paolo
Loi, Gabriella
Santonicola, Antonella
Iovino, Paola
author_facet Settembre, Carmela
D’Antonio, Elvira
Moscato, Paolo
Loi, Gabriella
Santonicola, Antonella
Iovino, Paola
author_sort Settembre, Carmela
collection PubMed
description The disorders of gut–brain interaction (DGBI) have been associated with Fibromyalgia (FM). However, there are no data about the relationship between FM and DGBI using Rome IV criteria. This study aimed to evaluate the prevalence of FM in patients with Irritable Bowel Syndrome (IBS) and/or Functional Dyspepsia (FD) and the prevalence of IBS and FD in FM patients using Rome IV criteria. DGBI patients and FM patients were recruited from two outpatient clinics devoted to DGBI and FM. All patients underwent a standardized gastrointestinal (GI) symptoms questionnaire. FM symptoms in DGBI patients were assessed through Fibromyalgia Rapid Screening Tool (FiRST) and Fibromyalgia Impact Questionnaire. Thereafter, the rheumatologists evaluated them. 49.0% of FM patients fulfilled the diagnostic criteria for IBS, 81.6% for FD with an overlap for both IBS/FD in 44.9%. IBS-C was the most prevalent IBS-subtype in DGBI patients, whereas IBS-M was the most prevalent in FM patients (p = 0.01). 45.3% of DGBI patients reported pathological FiRST scores. DGBI patients with FM showed the highest score at the standardized GI questionnaire followed by FM patients with DGBI and DGBI without FM. In conclusion DGBI are common in FM patients and vice versa. The presence of FD is extremely frequent in FM patients. A multidisciplinary approach should be routinely used for the management of these patients.
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spelling pubmed-88369922022-02-12 Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study Settembre, Carmela D’Antonio, Elvira Moscato, Paolo Loi, Gabriella Santonicola, Antonella Iovino, Paola J Clin Med Article The disorders of gut–brain interaction (DGBI) have been associated with Fibromyalgia (FM). However, there are no data about the relationship between FM and DGBI using Rome IV criteria. This study aimed to evaluate the prevalence of FM in patients with Irritable Bowel Syndrome (IBS) and/or Functional Dyspepsia (FD) and the prevalence of IBS and FD in FM patients using Rome IV criteria. DGBI patients and FM patients were recruited from two outpatient clinics devoted to DGBI and FM. All patients underwent a standardized gastrointestinal (GI) symptoms questionnaire. FM symptoms in DGBI patients were assessed through Fibromyalgia Rapid Screening Tool (FiRST) and Fibromyalgia Impact Questionnaire. Thereafter, the rheumatologists evaluated them. 49.0% of FM patients fulfilled the diagnostic criteria for IBS, 81.6% for FD with an overlap for both IBS/FD in 44.9%. IBS-C was the most prevalent IBS-subtype in DGBI patients, whereas IBS-M was the most prevalent in FM patients (p = 0.01). 45.3% of DGBI patients reported pathological FiRST scores. DGBI patients with FM showed the highest score at the standardized GI questionnaire followed by FM patients with DGBI and DGBI without FM. In conclusion DGBI are common in FM patients and vice versa. The presence of FD is extremely frequent in FM patients. A multidisciplinary approach should be routinely used for the management of these patients. MDPI 2022-02-03 /pmc/articles/PMC8836992/ /pubmed/35160260 http://dx.doi.org/10.3390/jcm11030809 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Settembre, Carmela
D’Antonio, Elvira
Moscato, Paolo
Loi, Gabriella
Santonicola, Antonella
Iovino, Paola
Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study
title Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study
title_full Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study
title_fullStr Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study
title_full_unstemmed Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study
title_short Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study
title_sort association among disorders of gut-brain interaction (dgbi) and fibromyalgia: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836992/
https://www.ncbi.nlm.nih.gov/pubmed/35160260
http://dx.doi.org/10.3390/jcm11030809
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