Cargando…

Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study

Previous studies have found an association between serum albumin levels and cognitive function. However, the results of this association are inconsistent, and the effect of Apolipoprotein E (APOE) on the association is less clear. Using retrospective cohort data (2008–2020), we investigated whether...

Descripción completa

Detalles Bibliográficos
Autores principales: Min, Jin-Young, Ha, Sang-Won, Yang, Soo-Hyun, Kang, Min-Ju, Jeong, Da-Eun, Min, Kyoung-Bok, Kim, Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836994/
https://www.ncbi.nlm.nih.gov/pubmed/35160273
http://dx.doi.org/10.3390/jcm11030822
_version_ 1784649814642786304
author Min, Jin-Young
Ha, Sang-Won
Yang, Soo-Hyun
Kang, Min-Ju
Jeong, Da-Eun
Min, Kyoung-Bok
Kim, Beom
author_facet Min, Jin-Young
Ha, Sang-Won
Yang, Soo-Hyun
Kang, Min-Ju
Jeong, Da-Eun
Min, Kyoung-Bok
Kim, Beom
author_sort Min, Jin-Young
collection PubMed
description Previous studies have found an association between serum albumin levels and cognitive function. However, the results of this association are inconsistent, and the effect of Apolipoprotein E (APOE) on the association is less clear. Using retrospective cohort data (2008–2020), we investigated whether chronic serum albumin was associated with cognitive performance in older adults. We further assessed how the APOE genotype modifies its relevance. A total of 2396 Korean veterans and their families who were aged 65 years or older in 2008 and who had both data of serum albumin and cognitive performance (assessed by the Mini-Mental State Examination, MMSE) were included for the current study. The serum albumin levels were divided into four groups by quartiles: Group 1 (<4.0 g/dL), Group 2 (4.0–4.19 g/dL), Group 3 (4.2–4.49 g/dL), and Group 4 (≥4.5 g/dL). APOE ε4 carriers were defined as the presence of at least one ε4 allele (ε2/4, ε3/4, ε4/4). After adjusting for age, sex, and medical conditions, serum albumin levels (assessed by the median serum albumin levels during the study period) were significantly associated with increases in the median MMSE scores (beta = 3.30, p < 0.0001). Compared with the lowest median albumin category (Group 1), the beta coefficients for the median MMSE score were significantly and gradually increased in Group 2 (beta = 2.80, p < 0.0001), Group 3 (beta = 3.71, p < 0.0001), and Group 4 (beta = 4.01, p < 0.0001), respectively. In the analysis of repeated albumin measures, similar patterns were observed in cognitive function. All regression coefficients were greater in ε4 carriers than in non-carriers. Our findings suggested that sustained lower serum albumin levels were associated with lower MMSE scores. This observation may be modified by APOE polymorphisms.
format Online
Article
Text
id pubmed-8836994
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88369942022-02-12 Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study Min, Jin-Young Ha, Sang-Won Yang, Soo-Hyun Kang, Min-Ju Jeong, Da-Eun Min, Kyoung-Bok Kim, Beom J Clin Med Article Previous studies have found an association between serum albumin levels and cognitive function. However, the results of this association are inconsistent, and the effect of Apolipoprotein E (APOE) on the association is less clear. Using retrospective cohort data (2008–2020), we investigated whether chronic serum albumin was associated with cognitive performance in older adults. We further assessed how the APOE genotype modifies its relevance. A total of 2396 Korean veterans and their families who were aged 65 years or older in 2008 and who had both data of serum albumin and cognitive performance (assessed by the Mini-Mental State Examination, MMSE) were included for the current study. The serum albumin levels were divided into four groups by quartiles: Group 1 (<4.0 g/dL), Group 2 (4.0–4.19 g/dL), Group 3 (4.2–4.49 g/dL), and Group 4 (≥4.5 g/dL). APOE ε4 carriers were defined as the presence of at least one ε4 allele (ε2/4, ε3/4, ε4/4). After adjusting for age, sex, and medical conditions, serum albumin levels (assessed by the median serum albumin levels during the study period) were significantly associated with increases in the median MMSE scores (beta = 3.30, p < 0.0001). Compared with the lowest median albumin category (Group 1), the beta coefficients for the median MMSE score were significantly and gradually increased in Group 2 (beta = 2.80, p < 0.0001), Group 3 (beta = 3.71, p < 0.0001), and Group 4 (beta = 4.01, p < 0.0001), respectively. In the analysis of repeated albumin measures, similar patterns were observed in cognitive function. All regression coefficients were greater in ε4 carriers than in non-carriers. Our findings suggested that sustained lower serum albumin levels were associated with lower MMSE scores. This observation may be modified by APOE polymorphisms. MDPI 2022-02-03 /pmc/articles/PMC8836994/ /pubmed/35160273 http://dx.doi.org/10.3390/jcm11030822 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Min, Jin-Young
Ha, Sang-Won
Yang, Soo-Hyun
Kang, Min-Ju
Jeong, Da-Eun
Min, Kyoung-Bok
Kim, Beom
Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study
title Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study
title_full Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study
title_fullStr Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study
title_full_unstemmed Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study
title_short Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study
title_sort chronic status of serum albumin and cognitive function: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836994/
https://www.ncbi.nlm.nih.gov/pubmed/35160273
http://dx.doi.org/10.3390/jcm11030822
work_keys_str_mv AT minjinyoung chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy
AT hasangwon chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy
AT yangsoohyun chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy
AT kangminju chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy
AT jeongdaeun chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy
AT minkyoungbok chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy
AT kimbeom chronicstatusofserumalbuminandcognitivefunctionaretrospectivecohortstudy