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The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis

One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseas...

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Autores principales: Czerwińska, Joanna, Owczarczyk-Saczonek, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837008/
https://www.ncbi.nlm.nih.gov/pubmed/35163760
http://dx.doi.org/10.3390/ijms23031840
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author Czerwińska, Joanna
Owczarczyk-Saczonek, Agnieszka
author_facet Czerwińska, Joanna
Owczarczyk-Saczonek, Agnieszka
author_sort Czerwińska, Joanna
collection PubMed
description One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseases such as psoriasis. The participation of neutrophils in the pathogenesis of that disease is dependent on an autoinflammatory feedback loop between neutrophils, lymphocytes, dendritic cells and keratinocytes. Our aim was to clarify the field of NET research in psoriasis and highlight the main factors required for NET generation, which may be a target of new therapies. This article presents a comphrehensive review concerning studies addressing the participation of neutrophils in the pathogenesis of psoriasis. Based on the available English-language literature, we discuss original papers presenting significant research findings which may help to understand and interpret the NET formation process in psoriasis, as well as the newest systematic reviews on PubMed. Next, the comparison, synthesis and summary of reported results were performed to clearly indicate the specific component of the NET which participates in the development of psoriasis.
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spelling pubmed-88370082022-02-12 The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis Czerwińska, Joanna Owczarczyk-Saczonek, Agnieszka Int J Mol Sci Review One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseases such as psoriasis. The participation of neutrophils in the pathogenesis of that disease is dependent on an autoinflammatory feedback loop between neutrophils, lymphocytes, dendritic cells and keratinocytes. Our aim was to clarify the field of NET research in psoriasis and highlight the main factors required for NET generation, which may be a target of new therapies. This article presents a comphrehensive review concerning studies addressing the participation of neutrophils in the pathogenesis of psoriasis. Based on the available English-language literature, we discuss original papers presenting significant research findings which may help to understand and interpret the NET formation process in psoriasis, as well as the newest systematic reviews on PubMed. Next, the comparison, synthesis and summary of reported results were performed to clearly indicate the specific component of the NET which participates in the development of psoriasis. MDPI 2022-02-06 /pmc/articles/PMC8837008/ /pubmed/35163760 http://dx.doi.org/10.3390/ijms23031840 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Czerwińska, Joanna
Owczarczyk-Saczonek, Agnieszka
The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
title The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
title_full The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
title_fullStr The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
title_full_unstemmed The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
title_short The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
title_sort role of the neutrophilic network in the pathogenesis of psoriasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837008/
https://www.ncbi.nlm.nih.gov/pubmed/35163760
http://dx.doi.org/10.3390/ijms23031840
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