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The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis
One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837008/ https://www.ncbi.nlm.nih.gov/pubmed/35163760 http://dx.doi.org/10.3390/ijms23031840 |
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author | Czerwińska, Joanna Owczarczyk-Saczonek, Agnieszka |
author_facet | Czerwińska, Joanna Owczarczyk-Saczonek, Agnieszka |
author_sort | Czerwińska, Joanna |
collection | PubMed |
description | One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseases such as psoriasis. The participation of neutrophils in the pathogenesis of that disease is dependent on an autoinflammatory feedback loop between neutrophils, lymphocytes, dendritic cells and keratinocytes. Our aim was to clarify the field of NET research in psoriasis and highlight the main factors required for NET generation, which may be a target of new therapies. This article presents a comphrehensive review concerning studies addressing the participation of neutrophils in the pathogenesis of psoriasis. Based on the available English-language literature, we discuss original papers presenting significant research findings which may help to understand and interpret the NET formation process in psoriasis, as well as the newest systematic reviews on PubMed. Next, the comparison, synthesis and summary of reported results were performed to clearly indicate the specific component of the NET which participates in the development of psoriasis. |
format | Online Article Text |
id | pubmed-8837008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88370082022-02-12 The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis Czerwińska, Joanna Owczarczyk-Saczonek, Agnieszka Int J Mol Sci Review One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseases such as psoriasis. The participation of neutrophils in the pathogenesis of that disease is dependent on an autoinflammatory feedback loop between neutrophils, lymphocytes, dendritic cells and keratinocytes. Our aim was to clarify the field of NET research in psoriasis and highlight the main factors required for NET generation, which may be a target of new therapies. This article presents a comphrehensive review concerning studies addressing the participation of neutrophils in the pathogenesis of psoriasis. Based on the available English-language literature, we discuss original papers presenting significant research findings which may help to understand and interpret the NET formation process in psoriasis, as well as the newest systematic reviews on PubMed. Next, the comparison, synthesis and summary of reported results were performed to clearly indicate the specific component of the NET which participates in the development of psoriasis. MDPI 2022-02-06 /pmc/articles/PMC8837008/ /pubmed/35163760 http://dx.doi.org/10.3390/ijms23031840 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Czerwińska, Joanna Owczarczyk-Saczonek, Agnieszka The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis |
title | The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis |
title_full | The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis |
title_fullStr | The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis |
title_full_unstemmed | The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis |
title_short | The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis |
title_sort | role of the neutrophilic network in the pathogenesis of psoriasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837008/ https://www.ncbi.nlm.nih.gov/pubmed/35163760 http://dx.doi.org/10.3390/ijms23031840 |
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