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The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation

Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinical and clinical studies. While the intracellular p...

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Detalles Bibliográficos
Autores principales:	Korver, Wouter, Wong, Alan, Gebremeskel, Simon, Negri, Gian Luca, Schanin, Julia, Chang, Katherine, Leung, John, Benet, Zachary, Luu, Thuy, Brock, Emily C., Luehrsen, Kenneth, Xu, Alan, Youngblood, Bradford A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837033/ https://www.ncbi.nlm.nih.gov/pubmed/35154156 http://dx.doi.org/10.3389/fimmu.2022.833728

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