The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad

Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis. However, its pathophysiology is not well established and there are currently very few predictive factors, none of which are actually useful, from a clinical perspective. The contribution of each of the vertices of V...

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Autores principales: Anton, Aina, Campreciós, Genís, Pérez-Campuzano, Valeria, Orts, Lara, García-Pagán, Joan Carles, Hernández-Gea, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837039/
https://www.ncbi.nlm.nih.gov/pubmed/35160251
http://dx.doi.org/10.3390/jcm11030800
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author Anton, Aina
Campreciós, Genís
Pérez-Campuzano, Valeria
Orts, Lara
García-Pagán, Joan Carles
Hernández-Gea, Virginia
author_facet Anton, Aina
Campreciós, Genís
Pérez-Campuzano, Valeria
Orts, Lara
García-Pagán, Joan Carles
Hernández-Gea, Virginia
author_sort Anton, Aina
collection PubMed
description Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis. However, its pathophysiology is not well established and there are currently very few predictive factors, none of which are actually useful, from a clinical perspective. The contribution of each of the vertices of Virchow’s triad, e.g., blood hypercoagulability, blood flow, and portal vein endothelial damage in the development of PVT is not clear. In this review, we aim to recapitulate the latest studies on the field of PVT development in order to understand its mechanisms and discuss some of the future directions in the study of this important complication of cirrhosis.
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spelling pubmed-88370392022-02-12 The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad Anton, Aina Campreciós, Genís Pérez-Campuzano, Valeria Orts, Lara García-Pagán, Joan Carles Hernández-Gea, Virginia J Clin Med Review Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis. However, its pathophysiology is not well established and there are currently very few predictive factors, none of which are actually useful, from a clinical perspective. The contribution of each of the vertices of Virchow’s triad, e.g., blood hypercoagulability, blood flow, and portal vein endothelial damage in the development of PVT is not clear. In this review, we aim to recapitulate the latest studies on the field of PVT development in order to understand its mechanisms and discuss some of the future directions in the study of this important complication of cirrhosis. MDPI 2022-02-02 /pmc/articles/PMC8837039/ /pubmed/35160251 http://dx.doi.org/10.3390/jcm11030800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Anton, Aina
Campreciós, Genís
Pérez-Campuzano, Valeria
Orts, Lara
García-Pagán, Joan Carles
Hernández-Gea, Virginia
The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad
title The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad
title_full The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad
title_fullStr The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad
title_full_unstemmed The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad
title_short The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad
title_sort pathophysiology of portal vein thrombosis in cirrhosis: getting deeper into virchow’s triad
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837039/
https://www.ncbi.nlm.nih.gov/pubmed/35160251
http://dx.doi.org/10.3390/jcm11030800
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