Cargando…

Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia

This retrospective case–control study aimed to evaluate whether Magnetic Resonance Imaging (MRI) enables differentiation of ankle arthritis in Juvenile Idiopathic Afrthritis JIA from ankle arthralgia of unknown aetiology in patients clinically suspected of JIA. Forty-four children, at ages 5–16, who...

Descripción completa

Detalles Bibliográficos
Autores principales: Ostrowska, Monika, Michalski, Emil, Gietka, Piotr, Mańczak, Małgorzata, Posadzy, Magdalena, Sudoł-Szopińska, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837053/
https://www.ncbi.nlm.nih.gov/pubmed/35160212
http://dx.doi.org/10.3390/jcm11030760
_version_ 1784649829921587200
author Ostrowska, Monika
Michalski, Emil
Gietka, Piotr
Mańczak, Małgorzata
Posadzy, Magdalena
Sudoł-Szopińska, Iwona
author_facet Ostrowska, Monika
Michalski, Emil
Gietka, Piotr
Mańczak, Małgorzata
Posadzy, Magdalena
Sudoł-Szopińska, Iwona
author_sort Ostrowska, Monika
collection PubMed
description This retrospective case–control study aimed to evaluate whether Magnetic Resonance Imaging (MRI) enables differentiation of ankle arthritis in Juvenile Idiopathic Afrthritis JIA from ankle arthralgia of unknown aetiology in patients clinically suspected of JIA. Forty-four children, at ages 5–16, who underwent MRI of the ankle from January 2016 to March 2021 for clinically suspected active ankle arthritis in the course of JIA were included. MRI findings in both groups—patients with the final diagnosis of JIA and without final diagnosis of JIA—were compared and scored. The sum of the scores of 22 ankle lesions in an individual patient (active, destructive and developmental), so-called the MRI summarized score, was calculated and tested in terms of the most optimal diagnosis of JIA. Interobserver agreement was calculated. Inflammatory features were seen on MRI in 38 out of all the included patients (86%). The most common lesions in both groups were effusion in the tibio-talar joint (68% in JIA and 64% in the arthralgia group) and effusion in subtalar joint (64% in JIA vs. 59% in the arthralgia group). In general, more lesions were identified in the JIA group than in non-JIA. However, only tenosynovitis was significantly more common in the JIA vs. non-JIA group (p = 0.031). The MRI summarized score did not allow for discrimination between ankle arthritis in JIA from non-JIA patients; the best levels of sensitivity (32%), specificity (91%), positive predictive value PPV (78%) and negative predictive value NPV (57%) were achieved only at the cut-off point of 10.
format Online
Article
Text
id pubmed-8837053
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88370532022-02-12 Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia Ostrowska, Monika Michalski, Emil Gietka, Piotr Mańczak, Małgorzata Posadzy, Magdalena Sudoł-Szopińska, Iwona J Clin Med Article This retrospective case–control study aimed to evaluate whether Magnetic Resonance Imaging (MRI) enables differentiation of ankle arthritis in Juvenile Idiopathic Afrthritis JIA from ankle arthralgia of unknown aetiology in patients clinically suspected of JIA. Forty-four children, at ages 5–16, who underwent MRI of the ankle from January 2016 to March 2021 for clinically suspected active ankle arthritis in the course of JIA were included. MRI findings in both groups—patients with the final diagnosis of JIA and without final diagnosis of JIA—were compared and scored. The sum of the scores of 22 ankle lesions in an individual patient (active, destructive and developmental), so-called the MRI summarized score, was calculated and tested in terms of the most optimal diagnosis of JIA. Interobserver agreement was calculated. Inflammatory features were seen on MRI in 38 out of all the included patients (86%). The most common lesions in both groups were effusion in the tibio-talar joint (68% in JIA and 64% in the arthralgia group) and effusion in subtalar joint (64% in JIA vs. 59% in the arthralgia group). In general, more lesions were identified in the JIA group than in non-JIA. However, only tenosynovitis was significantly more common in the JIA vs. non-JIA group (p = 0.031). The MRI summarized score did not allow for discrimination between ankle arthritis in JIA from non-JIA patients; the best levels of sensitivity (32%), specificity (91%), positive predictive value PPV (78%) and negative predictive value NPV (57%) were achieved only at the cut-off point of 10. MDPI 2022-01-30 /pmc/articles/PMC8837053/ /pubmed/35160212 http://dx.doi.org/10.3390/jcm11030760 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ostrowska, Monika
Michalski, Emil
Gietka, Piotr
Mańczak, Małgorzata
Posadzy, Magdalena
Sudoł-Szopińska, Iwona
Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia
title Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia
title_full Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia
title_fullStr Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia
title_full_unstemmed Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia
title_short Ankle Magnetic Resonance Imaging in Juvenile Idiopathic Arthritis Versus Non-Juvenile Idiopathic Arthritis Patients with Arthralgia
title_sort ankle magnetic resonance imaging in juvenile idiopathic arthritis versus non-juvenile idiopathic arthritis patients with arthralgia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837053/
https://www.ncbi.nlm.nih.gov/pubmed/35160212
http://dx.doi.org/10.3390/jcm11030760
work_keys_str_mv AT ostrowskamonika anklemagneticresonanceimaginginjuvenileidiopathicarthritisversusnonjuvenileidiopathicarthritispatientswitharthralgia
AT michalskiemil anklemagneticresonanceimaginginjuvenileidiopathicarthritisversusnonjuvenileidiopathicarthritispatientswitharthralgia
AT gietkapiotr anklemagneticresonanceimaginginjuvenileidiopathicarthritisversusnonjuvenileidiopathicarthritispatientswitharthralgia
AT manczakmałgorzata anklemagneticresonanceimaginginjuvenileidiopathicarthritisversusnonjuvenileidiopathicarthritispatientswitharthralgia
AT posadzymagdalena anklemagneticresonanceimaginginjuvenileidiopathicarthritisversusnonjuvenileidiopathicarthritispatientswitharthralgia
AT sudołszopinskaiwona anklemagneticresonanceimaginginjuvenileidiopathicarthritisversusnonjuvenileidiopathicarthritispatientswitharthralgia