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Combination of CLEC4M rs868875 G-Carriership and ABO O Genotypes May Predict Faster Decay of FVIII Infused in Hemophilia A Patients

The C-type lectin CLEC4M binds and internalizes factor VIII (FVIII). Common CLEC4M variants have been associated with FVIII pharmacokinetic (PK) profiles in hemophilia A (HA) patients. The two-compartment PK analysis of plasma-derived (pd-) and full length recombinant FVIII concentrates was conducte...

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Detalles Bibliográficos
Autores principales:	Lunghi, Barbara, Morfini, Massimo, Martinelli, Nicola, Linari, Silvia, Castaman, Giancarlo, Bernardi, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837058/ https://www.ncbi.nlm.nih.gov/pubmed/35160186 http://dx.doi.org/10.3390/jcm11030733

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