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Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw

Background: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous pl...

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Autores principales: Blatt, Sebastian, Krüger, Maximilian, Kämmerer, Peer W., Thiem, Daniel G. E., Matheis, Philipp, Eisenbeiß, Anne-Katrin, Wiltfang, Jörg, Al-Nawas, Bilal, Naujokat, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837070/
https://www.ncbi.nlm.nih.gov/pubmed/35160132
http://dx.doi.org/10.3390/jcm11030682
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author Blatt, Sebastian
Krüger, Maximilian
Kämmerer, Peer W.
Thiem, Daniel G. E.
Matheis, Philipp
Eisenbeiß, Anne-Katrin
Wiltfang, Jörg
Al-Nawas, Bilal
Naujokat, Hendrik
author_facet Blatt, Sebastian
Krüger, Maximilian
Kämmerer, Peer W.
Thiem, Daniel G. E.
Matheis, Philipp
Eisenbeiß, Anne-Katrin
Wiltfang, Jörg
Al-Nawas, Bilal
Naujokat, Hendrik
author_sort Blatt, Sebastian
collection PubMed
description Background: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous platelet concentrate as a possible additive in surgical therapy to optimize vascularization and, subsequently, resolution rates. Material and Methods: A non-interventional, prospective, multicenter study was conducted, and all patients with stage I-III MRONJ, undergoing antiresorptive therapy for an oncological indication, were included. The necrosis was treated surgically without (study arm A) or with (arm B) the addition of an autologous platelet concentrate (platelet-rich fibrin, PRF). Results: After 5, 14, and 42 days postoperative, wound healing (primary outcome: mucosal integrity) as well as downstaging, pain perception, and oral health-related quality of life (secondary outcome) were assessed via clinical evaluation. Among the 52 patients included, primarily with MRONJ stage I and II, the use of PRF as an additive in surgical therapy did not display a significant advantage for wound healing (p = 0.302), downstaging (p = 0.9), pain reduction (p = 0.169), or quality of life (p = 0.9). Summary: In conclusion, PRF as an adjunct did not significantly optimize wound healing. Further, no significant changes in terms of downstaging, pain sensation, and oral health-related quality of life were found.
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spelling pubmed-88370702022-02-12 Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw Blatt, Sebastian Krüger, Maximilian Kämmerer, Peer W. Thiem, Daniel G. E. Matheis, Philipp Eisenbeiß, Anne-Katrin Wiltfang, Jörg Al-Nawas, Bilal Naujokat, Hendrik J Clin Med Article Background: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous platelet concentrate as a possible additive in surgical therapy to optimize vascularization and, subsequently, resolution rates. Material and Methods: A non-interventional, prospective, multicenter study was conducted, and all patients with stage I-III MRONJ, undergoing antiresorptive therapy for an oncological indication, were included. The necrosis was treated surgically without (study arm A) or with (arm B) the addition of an autologous platelet concentrate (platelet-rich fibrin, PRF). Results: After 5, 14, and 42 days postoperative, wound healing (primary outcome: mucosal integrity) as well as downstaging, pain perception, and oral health-related quality of life (secondary outcome) were assessed via clinical evaluation. Among the 52 patients included, primarily with MRONJ stage I and II, the use of PRF as an additive in surgical therapy did not display a significant advantage for wound healing (p = 0.302), downstaging (p = 0.9), pain reduction (p = 0.169), or quality of life (p = 0.9). Summary: In conclusion, PRF as an adjunct did not significantly optimize wound healing. Further, no significant changes in terms of downstaging, pain sensation, and oral health-related quality of life were found. MDPI 2022-01-28 /pmc/articles/PMC8837070/ /pubmed/35160132 http://dx.doi.org/10.3390/jcm11030682 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blatt, Sebastian
Krüger, Maximilian
Kämmerer, Peer W.
Thiem, Daniel G. E.
Matheis, Philipp
Eisenbeiß, Anne-Katrin
Wiltfang, Jörg
Al-Nawas, Bilal
Naujokat, Hendrik
Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
title Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
title_full Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
title_fullStr Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
title_full_unstemmed Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
title_short Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
title_sort non-interventional prospective observational study of platelet rich fibrin as a therapy adjunctive in patients with medication-related osteonecrosis of the jaw
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837070/
https://www.ncbi.nlm.nih.gov/pubmed/35160132
http://dx.doi.org/10.3390/jcm11030682
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