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Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015

Background: Chronic inflammatory diseases are linked to an increased risk of atherothrombotic events, but the risk associated with inflammatory bowel disease (IBD) is controversial. We therefore examined the risk of and risk factors for myocardial infarction (MI) and stroke in IBD patients. Methods:...

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Autores principales: Golovics, Petra Anna, Verdon, Christine, Wetwittayakhlang, Panu, Filliter, Christopher, Gonczi, Lorant, Hahn, Gustavo Drügg, Wild, Gary E., Afif, Waqqas, Bitton, Alain, Bessissow, Talat, Brassard, Paul, Lakatos, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837182/
https://www.ncbi.nlm.nih.gov/pubmed/35160136
http://dx.doi.org/10.3390/jcm11030686
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author Golovics, Petra Anna
Verdon, Christine
Wetwittayakhlang, Panu
Filliter, Christopher
Gonczi, Lorant
Hahn, Gustavo Drügg
Wild, Gary E.
Afif, Waqqas
Bitton, Alain
Bessissow, Talat
Brassard, Paul
Lakatos, Peter L.
author_facet Golovics, Petra Anna
Verdon, Christine
Wetwittayakhlang, Panu
Filliter, Christopher
Gonczi, Lorant
Hahn, Gustavo Drügg
Wild, Gary E.
Afif, Waqqas
Bitton, Alain
Bessissow, Talat
Brassard, Paul
Lakatos, Peter L.
author_sort Golovics, Petra Anna
collection PubMed
description Background: Chronic inflammatory diseases are linked to an increased risk of atherothrombotic events, but the risk associated with inflammatory bowel disease (IBD) is controversial. We therefore examined the risk of and risk factors for myocardial infarction (MI) and stroke in IBD patients. Methods: We used the public health administrative database from the Province of Quebec, Canada, to identify IBD patients newly diagnosed between 1996 and 2015. The incidence and prevalence of MI and stroke in IBD patients were compared to those for the Canadian population. Results: A cohort of 35,985 IBD patients was identified. The prevalence but not incidence rates of MI were higher in IBD patients (prevalence: 3.98%; incidence: 0.234) compared to the Canadian rates (prevalence: 2.0%; incidence: 0.220), while the prevalence and incidence rates of stroke were not significantly higher in the IBD patients (prevalence: 2.98%; incidence: 0.122, vs. Canadian rates: prevalence: 2.60%; incidence: 0.297). We identified age, female gender, hyperlipidemia, diabetes, and hypertension (p < 0.001 for each) as significant risk factors associated with MI and stroke in IBD. Exposure to biologics was associated with a higher incidence of MI (IRR: 1.51; 95% CI: 0.82–2.76; p = 0.07) in the insured IBD population. Conclusions: An increased prevalence but not incidence of MI and no increased risk of stroke were identified in this population-based IBD cohort.
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spelling pubmed-88371822022-02-12 Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015 Golovics, Petra Anna Verdon, Christine Wetwittayakhlang, Panu Filliter, Christopher Gonczi, Lorant Hahn, Gustavo Drügg Wild, Gary E. Afif, Waqqas Bitton, Alain Bessissow, Talat Brassard, Paul Lakatos, Peter L. J Clin Med Article Background: Chronic inflammatory diseases are linked to an increased risk of atherothrombotic events, but the risk associated with inflammatory bowel disease (IBD) is controversial. We therefore examined the risk of and risk factors for myocardial infarction (MI) and stroke in IBD patients. Methods: We used the public health administrative database from the Province of Quebec, Canada, to identify IBD patients newly diagnosed between 1996 and 2015. The incidence and prevalence of MI and stroke in IBD patients were compared to those for the Canadian population. Results: A cohort of 35,985 IBD patients was identified. The prevalence but not incidence rates of MI were higher in IBD patients (prevalence: 3.98%; incidence: 0.234) compared to the Canadian rates (prevalence: 2.0%; incidence: 0.220), while the prevalence and incidence rates of stroke were not significantly higher in the IBD patients (prevalence: 2.98%; incidence: 0.122, vs. Canadian rates: prevalence: 2.60%; incidence: 0.297). We identified age, female gender, hyperlipidemia, diabetes, and hypertension (p < 0.001 for each) as significant risk factors associated with MI and stroke in IBD. Exposure to biologics was associated with a higher incidence of MI (IRR: 1.51; 95% CI: 0.82–2.76; p = 0.07) in the insured IBD population. Conclusions: An increased prevalence but not incidence of MI and no increased risk of stroke were identified in this population-based IBD cohort. MDPI 2022-01-28 /pmc/articles/PMC8837182/ /pubmed/35160136 http://dx.doi.org/10.3390/jcm11030686 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Golovics, Petra Anna
Verdon, Christine
Wetwittayakhlang, Panu
Filliter, Christopher
Gonczi, Lorant
Hahn, Gustavo Drügg
Wild, Gary E.
Afif, Waqqas
Bitton, Alain
Bessissow, Talat
Brassard, Paul
Lakatos, Peter L.
Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015
title Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015
title_full Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015
title_fullStr Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015
title_full_unstemmed Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015
title_short Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996–2015
title_sort increased prevalence of myocardial infarction and stable stroke proportions in patients with inflammatory bowel diseases in quebec in 1996–2015
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837182/
https://www.ncbi.nlm.nih.gov/pubmed/35160136
http://dx.doi.org/10.3390/jcm11030686
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