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Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation

The functional interleukin 6 (IL-6) signaling complex is a hexameric structure composed of IL-6, IL-6Rα, and the signaling receptor gp130. There are three different modes of IL-6 signaling, classic signaling, trans-signaling, and trans-presentation, which are not functionally redundant and mediate p...

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Detalles Bibliográficos
Autores principales:	Chou, Chun-Chi, Hua, Kuo-Tai, Chen, Min-Wei, Wu, Chin-Jui, Hsu, Chun-Hua, Wang, Jann-Tay, Hsiao, Michael, Wei, Lin-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837245/ https://www.ncbi.nlm.nih.gov/pubmed/35133941 http://dx.doi.org/10.1080/19420862.2022.2029675

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