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Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27

Cyclin-dependent kinase 4 (CDK4) is a master integrator that couples mitogenic/oncogenic signaling with the cell division cycle. It is deregulated in most cancers and inhibitors of CDK4 have become standard of care drugs for metastatic estrogen-receptor positive breast cancers and are being evaluate...

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Detalles Bibliográficos
Autores principales:	Coulonval, Katia, Vercruysse, Vincent, Paternot, Sabine, Pita, Jaime M., Corman, Robert, Raspé, Eric, Roger, Pierre P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837260/ https://www.ncbi.nlm.nih.gov/pubmed/34913830 http://dx.doi.org/10.1080/15384101.2021.1984663

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