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Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease

OBJECTIVE: Our study aims to investigate the role of the ABO blood group in the development and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients with dialysis. METHODS: A total of 408 ESRD patients with dialysis between January 2010 and December 2020 were enrolled...

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Autores principales: Ye, Zixiang, Wu, Yaxin, Tu, Yimin, Chen, Mulei, Gao, Yanxiang, Shi, Linying, Li, Peizhao, Xie, Enmin, Guo, Ziyu, Li, Qing, Yu, Xiaozhai, Li, Yike, Niu, Wenquan, Ren, Jingyi, Zheng, Jingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837269/
https://www.ncbi.nlm.nih.gov/pubmed/35155621
http://dx.doi.org/10.3389/fcvm.2021.821540
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author Ye, Zixiang
Wu, Yaxin
Tu, Yimin
Chen, Mulei
Gao, Yanxiang
Shi, Linying
Li, Peizhao
Xie, Enmin
Guo, Ziyu
Li, Qing
Yu, Xiaozhai
Li, Yike
Niu, Wenquan
Ren, Jingyi
Zheng, Jingang
author_facet Ye, Zixiang
Wu, Yaxin
Tu, Yimin
Chen, Mulei
Gao, Yanxiang
Shi, Linying
Li, Peizhao
Xie, Enmin
Guo, Ziyu
Li, Qing
Yu, Xiaozhai
Li, Yike
Niu, Wenquan
Ren, Jingyi
Zheng, Jingang
author_sort Ye, Zixiang
collection PubMed
description OBJECTIVE: Our study aims to investigate the role of the ABO blood group in the development and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients with dialysis. METHODS: A total of 408 ESRD patients with dialysis between January 2010 and December 2020 were enrolled including 204 patients diagnosed with CAD undergoing coronary angiography for the first time, and baseline characteristics as well as Gensini score (GS) were collected. Logistic regression analysis and linear regression analysis were performed to evaluate the relation of ABO blood types to the risk and severity of CAD, respectively. RESULTS: Blood group O frequency was significantly low in dialysis ESRD patients with CAD (25 vs. 38.24%) compared with the non-CAD patients and multivariable logistic regression showed blood group O was negatively associated with the risk of CAD [adjusted odds ratio (OR) = 0.33, 95% CI = 0.19–0.60, p < 0.001] as well as the GS tertiles (adjusted OR = 0.23, 95% CI = 0.11–0.49, p < 0.001) compared with A blood group. Blood group A, B, and AB were positively associated with the high Gensini tertile compared with O blood group (adjusted OR = 4.26, 95% CI = 2.03–8.93, p < 0.001; adjusted OR = 2.39, 95% CI = 1.11–5.13, p < 0.05; adjusted OR = 4.33, 95% CI = 1.40–13.35, P < 0.05). Similarly, multivariable linear regression results revealed O blood type was negatively associated with the GS (β = −26.129, 95% CI = −40.094 to −12.164, p < 0.001). CONCLUSION: This case-control study demonstrated that blood group O was a potential independent protective factor for the risk and severity of CAD in ESRD patients with dialysis.
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spelling pubmed-88372692022-02-12 Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease Ye, Zixiang Wu, Yaxin Tu, Yimin Chen, Mulei Gao, Yanxiang Shi, Linying Li, Peizhao Xie, Enmin Guo, Ziyu Li, Qing Yu, Xiaozhai Li, Yike Niu, Wenquan Ren, Jingyi Zheng, Jingang Front Cardiovasc Med Cardiovascular Medicine OBJECTIVE: Our study aims to investigate the role of the ABO blood group in the development and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients with dialysis. METHODS: A total of 408 ESRD patients with dialysis between January 2010 and December 2020 were enrolled including 204 patients diagnosed with CAD undergoing coronary angiography for the first time, and baseline characteristics as well as Gensini score (GS) were collected. Logistic regression analysis and linear regression analysis were performed to evaluate the relation of ABO blood types to the risk and severity of CAD, respectively. RESULTS: Blood group O frequency was significantly low in dialysis ESRD patients with CAD (25 vs. 38.24%) compared with the non-CAD patients and multivariable logistic regression showed blood group O was negatively associated with the risk of CAD [adjusted odds ratio (OR) = 0.33, 95% CI = 0.19–0.60, p < 0.001] as well as the GS tertiles (adjusted OR = 0.23, 95% CI = 0.11–0.49, p < 0.001) compared with A blood group. Blood group A, B, and AB were positively associated with the high Gensini tertile compared with O blood group (adjusted OR = 4.26, 95% CI = 2.03–8.93, p < 0.001; adjusted OR = 2.39, 95% CI = 1.11–5.13, p < 0.05; adjusted OR = 4.33, 95% CI = 1.40–13.35, P < 0.05). Similarly, multivariable linear regression results revealed O blood type was negatively associated with the GS (β = −26.129, 95% CI = −40.094 to −12.164, p < 0.001). CONCLUSION: This case-control study demonstrated that blood group O was a potential independent protective factor for the risk and severity of CAD in ESRD patients with dialysis. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8837269/ /pubmed/35155621 http://dx.doi.org/10.3389/fcvm.2021.821540 Text en Copyright © 2022 Ye, Wu, Tu, Chen, Gao, Shi, Li, Xie, Guo, Li, Yu, Li, Niu, Ren and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Ye, Zixiang
Wu, Yaxin
Tu, Yimin
Chen, Mulei
Gao, Yanxiang
Shi, Linying
Li, Peizhao
Xie, Enmin
Guo, Ziyu
Li, Qing
Yu, Xiaozhai
Li, Yike
Niu, Wenquan
Ren, Jingyi
Zheng, Jingang
Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease
title Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease
title_full Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease
title_fullStr Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease
title_full_unstemmed Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease
title_short Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease
title_sort blood group o protect end-stage renal disease patients with dialysis from coronary artery disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837269/
https://www.ncbi.nlm.nih.gov/pubmed/35155621
http://dx.doi.org/10.3389/fcvm.2021.821540
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