A New Perspective of COVID-19 Infection: An Epigenetics Point of View

Coronavirus disease 2019 (COVID-2019) started in Wuhan, China, in December 2019. Angiotensin-converting enzyme 2 (ACE2) receptor was one of the most important genes related to the entrance of the virus to the host. Until now, several variations have been identified in ACE2 and related transmembrane...

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Autores principales: Ozturkler, Ziya, Kalkan, Rasime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837408/
https://www.ncbi.nlm.nih.gov/pubmed/35169776
http://dx.doi.org/10.1055/s-0041-1736565
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author Ozturkler, Ziya
Kalkan, Rasime
author_facet Ozturkler, Ziya
Kalkan, Rasime
author_sort Ozturkler, Ziya
collection PubMed
description Coronavirus disease 2019 (COVID-2019) started in Wuhan, China, in December 2019. Angiotensin-converting enzyme 2 (ACE2) receptor was one of the most important genes related to the entrance of the virus to the host. Until now, several variations have been identified in ACE2 and related transmembrane protease serine 2. Epigenetic modifications not only play an important role during the maintenance of genome and cellular homoeostasis but also for the etiopathophysiology of the virus infection. Studies showed methylation of ACE2 was changed to depend on host and age of the host during the viral infection. In this study, we provided an epigenetics point of view to the coronavirus infection. We highlight the importance of epigenetic modifications during viral replication and infection and their interaction with COVID-19 susceptibility and host viral response.
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spelling pubmed-88374082022-02-14 A New Perspective of COVID-19 Infection: An Epigenetics Point of View Ozturkler, Ziya Kalkan, Rasime Glob Med Genet Coronavirus disease 2019 (COVID-2019) started in Wuhan, China, in December 2019. Angiotensin-converting enzyme 2 (ACE2) receptor was one of the most important genes related to the entrance of the virus to the host. Until now, several variations have been identified in ACE2 and related transmembrane protease serine 2. Epigenetic modifications not only play an important role during the maintenance of genome and cellular homoeostasis but also for the etiopathophysiology of the virus infection. Studies showed methylation of ACE2 was changed to depend on host and age of the host during the viral infection. In this study, we provided an epigenetics point of view to the coronavirus infection. We highlight the importance of epigenetic modifications during viral replication and infection and their interaction with COVID-19 susceptibility and host viral response. Georg Thieme Verlag KG 2021-10-19 /pmc/articles/PMC8837408/ /pubmed/35169776 http://dx.doi.org/10.1055/s-0041-1736565 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Ozturkler, Ziya
Kalkan, Rasime
A New Perspective of COVID-19 Infection: An Epigenetics Point of View
title A New Perspective of COVID-19 Infection: An Epigenetics Point of View
title_full A New Perspective of COVID-19 Infection: An Epigenetics Point of View
title_fullStr A New Perspective of COVID-19 Infection: An Epigenetics Point of View
title_full_unstemmed A New Perspective of COVID-19 Infection: An Epigenetics Point of View
title_short A New Perspective of COVID-19 Infection: An Epigenetics Point of View
title_sort new perspective of covid-19 infection: an epigenetics point of view
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837408/
https://www.ncbi.nlm.nih.gov/pubmed/35169776
http://dx.doi.org/10.1055/s-0041-1736565
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