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Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic, Pneumonia, and Severe Disease Caused by the Delta Variant: Real World Study and Evidence — China, 2021

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? Effectiveness of China’s 2 inactivated vaccines (BBIBP-CorV and CoronaVac) against pre-Delta severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants ranged from 47% to over 90%, depending on the clinical endpoint, and with greater effectiveness a...

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Detalles Bibliográficos
Autores principales: Wu, Dan, Zhang, Yanyang, Tang, Lin, Wang, Fuzhen, Ye, Ying, Ma, Chao, Zheng, Hui, Yu, Wenzhou, Cao, Lei, Song, Yifan, Reyimu, Abuduwaili, Zhang, Xiaoxiao, Wang, Haifeng, Nie, Yifei, Lu, Mingxia, Qi, Muge, Li, Jun, Wang, Ruolin, Yang, Kaichao, Wang, Changshuang, Rodewald, Lawrence Everett, Gao, Geroge Fu, An, Zhijie, Yin, Zundong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837442/
https://www.ncbi.nlm.nih.gov/pubmed/35186369
http://dx.doi.org/10.46234/ccdcw2022.009
Descripción
Sumario:WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? Effectiveness of China’s 2 inactivated vaccines (BBIBP-CorV and CoronaVac) against pre-Delta severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants ranged from 47% to over 90%, depending on the clinical endpoint, and with greater effectiveness against more severe coronavirus disease 2019 (COVID-19). During an outbreak in Guangdong, inactivated vaccine effectiveness (VE) against the Delta variant was 70% for symptomatic infection and 100% for severe COVID-19. However, separate or combined VE estimates for the two inactivated vaccines against Delta are not available. WHAT IS ADDED BY THIS REPORT? In an outbreak that started in a hospital, VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant were 51%, 61%, and 82%. Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%. VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar, and partial vaccination was ineffective. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19, COVID-19 pneumonia, and severe COVID-19 caused by the Delta variant. Completion of the completed primary vaccination with two doses is necessary for protection from Delta.