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Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity

The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10), 7α, 8β, 12β, 18-tetrahydroxy pimar-15-ene (11), 3β, 8β,...

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Autores principales: Pandey, Jitendra, Hwang, Bang Yeon, Lee, Hyeong-Kyu, Poudel, Amrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837446/
https://www.ncbi.nlm.nih.gov/pubmed/35154345
http://dx.doi.org/10.1155/2022/5178880
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author Pandey, Jitendra
Hwang, Bang Yeon
Lee, Hyeong-Kyu
Poudel, Amrit
author_facet Pandey, Jitendra
Hwang, Bang Yeon
Lee, Hyeong-Kyu
Poudel, Amrit
author_sort Pandey, Jitendra
collection PubMed
description The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10), 7α, 8β, 12β, 18-tetrahydroxy pimar-15-ene (11), 3β, 8β, 11β, 12α, 18-pentahydroxy pimar-15-ene (12), 12β acetoxy, 8β, 3β, 18-trihydroxy pimar-15-ene (13), and 3β acetoxy, 8β, 12β, 18-trihydroxy pimar-15-ene (14), along with nine known compounds. The structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated new pimarane diterpenoids were examined for antimicrobial activity against Gram-negative and Gram-positive bacteria strains. Among them, the compound 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10) was most effective, exhibiting minimum inhibitory concentration (MIC) values of 15.62 µg/mL against Staphylococcus epidermidis, 31.25 µg/mL against Staphylococcus aureus, 62.5 µg/mL against Pseudomonas aeruginosa, and 125 µg/mL against Escherichia coli.
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spelling pubmed-88374462022-02-12 Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity Pandey, Jitendra Hwang, Bang Yeon Lee, Hyeong-Kyu Poudel, Amrit Evid Based Complement Alternat Med Research Article The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10), 7α, 8β, 12β, 18-tetrahydroxy pimar-15-ene (11), 3β, 8β, 11β, 12α, 18-pentahydroxy pimar-15-ene (12), 12β acetoxy, 8β, 3β, 18-trihydroxy pimar-15-ene (13), and 3β acetoxy, 8β, 12β, 18-trihydroxy pimar-15-ene (14), along with nine known compounds. The structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated new pimarane diterpenoids were examined for antimicrobial activity against Gram-negative and Gram-positive bacteria strains. Among them, the compound 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10) was most effective, exhibiting minimum inhibitory concentration (MIC) values of 15.62 µg/mL against Staphylococcus epidermidis, 31.25 µg/mL against Staphylococcus aureus, 62.5 µg/mL against Pseudomonas aeruginosa, and 125 µg/mL against Escherichia coli. Hindawi 2022-02-04 /pmc/articles/PMC8837446/ /pubmed/35154345 http://dx.doi.org/10.1155/2022/5178880 Text en Copyright © 2022 Jitendra Pandey et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pandey, Jitendra
Hwang, Bang Yeon
Lee, Hyeong-Kyu
Poudel, Amrit
Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
title Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
title_full Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
title_fullStr Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
title_full_unstemmed Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
title_short Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
title_sort pimarane diterpenoids from aerial parts of lycopus lucidus and their antimicrobial activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837446/
https://www.ncbi.nlm.nih.gov/pubmed/35154345
http://dx.doi.org/10.1155/2022/5178880
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