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Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity
The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10), 7α, 8β, 12β, 18-tetrahydroxy pimar-15-ene (11), 3β, 8β,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837446/ https://www.ncbi.nlm.nih.gov/pubmed/35154345 http://dx.doi.org/10.1155/2022/5178880 |
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author | Pandey, Jitendra Hwang, Bang Yeon Lee, Hyeong-Kyu Poudel, Amrit |
author_facet | Pandey, Jitendra Hwang, Bang Yeon Lee, Hyeong-Kyu Poudel, Amrit |
author_sort | Pandey, Jitendra |
collection | PubMed |
description | The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10), 7α, 8β, 12β, 18-tetrahydroxy pimar-15-ene (11), 3β, 8β, 11β, 12α, 18-pentahydroxy pimar-15-ene (12), 12β acetoxy, 8β, 3β, 18-trihydroxy pimar-15-ene (13), and 3β acetoxy, 8β, 12β, 18-trihydroxy pimar-15-ene (14), along with nine known compounds. The structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated new pimarane diterpenoids were examined for antimicrobial activity against Gram-negative and Gram-positive bacteria strains. Among them, the compound 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10) was most effective, exhibiting minimum inhibitory concentration (MIC) values of 15.62 µg/mL against Staphylococcus epidermidis, 31.25 µg/mL against Staphylococcus aureus, 62.5 µg/mL against Pseudomonas aeruginosa, and 125 µg/mL against Escherichia coli. |
format | Online Article Text |
id | pubmed-8837446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88374462022-02-12 Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity Pandey, Jitendra Hwang, Bang Yeon Lee, Hyeong-Kyu Poudel, Amrit Evid Based Complement Alternat Med Research Article The ethyl acetate fraction obtained from aerial parts of L. lucidus was subjected for isolation of new bioactive compounds, which enabled isolation of five new pimarane-type diterpenoids, namely, 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10), 7α, 8β, 12β, 18-tetrahydroxy pimar-15-ene (11), 3β, 8β, 11β, 12α, 18-pentahydroxy pimar-15-ene (12), 12β acetoxy, 8β, 3β, 18-trihydroxy pimar-15-ene (13), and 3β acetoxy, 8β, 12β, 18-trihydroxy pimar-15-ene (14), along with nine known compounds. The structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated new pimarane diterpenoids were examined for antimicrobial activity against Gram-negative and Gram-positive bacteria strains. Among them, the compound 3β, 8β, 12β, 18-tetrahydroxy pimar-15-ene (10) was most effective, exhibiting minimum inhibitory concentration (MIC) values of 15.62 µg/mL against Staphylococcus epidermidis, 31.25 µg/mL against Staphylococcus aureus, 62.5 µg/mL against Pseudomonas aeruginosa, and 125 µg/mL against Escherichia coli. Hindawi 2022-02-04 /pmc/articles/PMC8837446/ /pubmed/35154345 http://dx.doi.org/10.1155/2022/5178880 Text en Copyright © 2022 Jitendra Pandey et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pandey, Jitendra Hwang, Bang Yeon Lee, Hyeong-Kyu Poudel, Amrit Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity |
title | Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity |
title_full | Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity |
title_fullStr | Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity |
title_full_unstemmed | Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity |
title_short | Pimarane Diterpenoids from Aerial Parts of Lycopus lucidus and Their Antimicrobial Activity |
title_sort | pimarane diterpenoids from aerial parts of lycopus lucidus and their antimicrobial activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837446/ https://www.ncbi.nlm.nih.gov/pubmed/35154345 http://dx.doi.org/10.1155/2022/5178880 |
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