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Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19

OBJECTIVE: The microbiota-gut-brain axis is a key pathway perturbed by prolonged stressors to produce brain and behavioral disorders. Frontline healthcare workers (FHWs) fighting against COVID-19 typically experience stressful event sequences and manifest some mental symptoms; however, the role of g...

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Autores principales: Gao, Fengjie, Guo, Ruijin, Ma, Qingyan, Li, Yening, Wang, Wei, Fan, Yajuan, Ju, Yanmei, Zhao, Binbin, Gao, Yuan, Qian, Li, Yang, Zai, He, Xiaoyan, Jin, Xiaoying, Liu, Yixin, Peng, Yuan, Chen, Ce, Chen, Yunchun, Gao, Chengge, Zhu, Feng, Ma, Xiancang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837476/
https://www.ncbi.nlm.nih.gov/pubmed/35157946
http://dx.doi.org/10.1016/j.jad.2022.02.024
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author Gao, Fengjie
Guo, Ruijin
Ma, Qingyan
Li, Yening
Wang, Wei
Fan, Yajuan
Ju, Yanmei
Zhao, Binbin
Gao, Yuan
Qian, Li
Yang, Zai
He, Xiaoyan
Jin, Xiaoying
Liu, Yixin
Peng, Yuan
Chen, Ce
Chen, Yunchun
Gao, Chengge
Zhu, Feng
Ma, Xiancang
author_facet Gao, Fengjie
Guo, Ruijin
Ma, Qingyan
Li, Yening
Wang, Wei
Fan, Yajuan
Ju, Yanmei
Zhao, Binbin
Gao, Yuan
Qian, Li
Yang, Zai
He, Xiaoyan
Jin, Xiaoying
Liu, Yixin
Peng, Yuan
Chen, Ce
Chen, Yunchun
Gao, Chengge
Zhu, Feng
Ma, Xiancang
author_sort Gao, Fengjie
collection PubMed
description OBJECTIVE: The microbiota-gut-brain axis is a key pathway perturbed by prolonged stressors to produce brain and behavioral disorders. Frontline healthcare workers (FHWs) fighting against COVID-19 typically experience stressful event sequences and manifest some mental symptoms; however, the role of gut microbiota in such stress-induced mental problems remains unclear. We investigated the association between the psychological stress of FHW and gut microbiota. METHODS: We used full-length 16S rRNA gene sequencing to characterize the longitudinal changes in gut microbiota and investigated the impact of microbial changes on FHWs' mental status. RESULTS: Stressful events induced significant depression, anxiety, and stress in FHWs and disrupted the gut microbiome; gut dysbiosis persisted for at least half a year. Different microbes followed discrete trajectories during the half-year of follow-up. Microbes associated with mental health were mainly Faecalibacterium spp. and [Eubacterium] eligens group spp. with anti-inflammatory effects. Of note, the prediction model indicated that low abundance of [Eubacterium] hallii group uncultured bacterium and high abundance of Bacteroides eggerthii at Day 0 (immediately after the two-month frontline work) were significant determinants of the reappearance of post-traumatic stress symptoms in FHWs. LIMITATIONS: The lack of metabolomic evidence and animal experiments result in the unclear mechanism of gut dysbiosis-related stress symptoms. CONCLUSION: The stressful event sequences of fighting against COVID-19 induce characteristic longitudinal changes in gut microbiota, which underlies dynamic mental state changes.
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spelling pubmed-88374762022-02-14 Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19 Gao, Fengjie Guo, Ruijin Ma, Qingyan Li, Yening Wang, Wei Fan, Yajuan Ju, Yanmei Zhao, Binbin Gao, Yuan Qian, Li Yang, Zai He, Xiaoyan Jin, Xiaoying Liu, Yixin Peng, Yuan Chen, Ce Chen, Yunchun Gao, Chengge Zhu, Feng Ma, Xiancang J Affect Disord Research Paper OBJECTIVE: The microbiota-gut-brain axis is a key pathway perturbed by prolonged stressors to produce brain and behavioral disorders. Frontline healthcare workers (FHWs) fighting against COVID-19 typically experience stressful event sequences and manifest some mental symptoms; however, the role of gut microbiota in such stress-induced mental problems remains unclear. We investigated the association between the psychological stress of FHW and gut microbiota. METHODS: We used full-length 16S rRNA gene sequencing to characterize the longitudinal changes in gut microbiota and investigated the impact of microbial changes on FHWs' mental status. RESULTS: Stressful events induced significant depression, anxiety, and stress in FHWs and disrupted the gut microbiome; gut dysbiosis persisted for at least half a year. Different microbes followed discrete trajectories during the half-year of follow-up. Microbes associated with mental health were mainly Faecalibacterium spp. and [Eubacterium] eligens group spp. with anti-inflammatory effects. Of note, the prediction model indicated that low abundance of [Eubacterium] hallii group uncultured bacterium and high abundance of Bacteroides eggerthii at Day 0 (immediately after the two-month frontline work) were significant determinants of the reappearance of post-traumatic stress symptoms in FHWs. LIMITATIONS: The lack of metabolomic evidence and animal experiments result in the unclear mechanism of gut dysbiosis-related stress symptoms. CONCLUSION: The stressful event sequences of fighting against COVID-19 induce characteristic longitudinal changes in gut microbiota, which underlies dynamic mental state changes. Elsevier B.V. 2022-04-15 2022-02-12 /pmc/articles/PMC8837476/ /pubmed/35157946 http://dx.doi.org/10.1016/j.jad.2022.02.024 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Gao, Fengjie
Guo, Ruijin
Ma, Qingyan
Li, Yening
Wang, Wei
Fan, Yajuan
Ju, Yanmei
Zhao, Binbin
Gao, Yuan
Qian, Li
Yang, Zai
He, Xiaoyan
Jin, Xiaoying
Liu, Yixin
Peng, Yuan
Chen, Ce
Chen, Yunchun
Gao, Chengge
Zhu, Feng
Ma, Xiancang
Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19
title Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19
title_full Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19
title_fullStr Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19
title_full_unstemmed Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19
title_short Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19
title_sort stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against covid-19
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837476/
https://www.ncbi.nlm.nih.gov/pubmed/35157946
http://dx.doi.org/10.1016/j.jad.2022.02.024
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