Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

PURPOSE: Antibody-drug conjugates (ADCs), which are monoclonal antibodies (mAbs) conjugated with highly toxic payloads, achieve high tumor killing efficacy due to the specific delivery of payloads in accordance with mAbs’ function. On the other hand, the conjugation of payloads often increases the h...

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Detalles Bibliográficos
Autores principales: Aoyama, Michihiko, Tada, Minoru, Yokoo, Hidetomo, Demizu, Yosuke, Ishii-Watabe, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837541/
https://www.ncbi.nlm.nih.gov/pubmed/34961908
http://dx.doi.org/10.1007/s11095-021-03158-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837541/
https://www.ncbi.nlm.nih.gov/pubmed/34961908
http://dx.doi.org/10.1007/s11095-021-03158-x

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