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Post-VX exposure treatment of rats with engineered phosphotriesterases

The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators and competitive muscarinic receptor antagonists, is insufficient. Recently, two engineered mutants of the Brevundimonas diminuta phosphotrie...

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Detalles Bibliográficos
Autores principales:	Stigler, Lisa, Köhler, Anja, Koller, Marianne, Job, Laura, Escher, Benjamin, Potschka, Heidrun, Thiermann, Horst, Skerra, Arne, Worek, Franz, Wille, Timo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Molecular Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837561/ https://www.ncbi.nlm.nih.gov/pubmed/34962578 http://dx.doi.org/10.1007/s00204-021-03199-6

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