Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

In natural product discovery programs, the power of synthetic chemistry is often leveraged for the total synthesis and diversification of characterized metabolites. The synthesis of structures that are bioinformatically predicted to arise from uncharacterized biosynthetic gene clusters (BGCs) provid...

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Detalles Bibliográficos
Autores principales: Wang, Zongqiang, Forelli, Nicholas, Hernandez, Yozen, Ternei, Melinda, Brady, Sean F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837603/
https://www.ncbi.nlm.nih.gov/pubmed/35149673
http://dx.doi.org/10.1038/s41467-022-28292-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837603/
https://www.ncbi.nlm.nih.gov/pubmed/35149673
http://dx.doi.org/10.1038/s41467-022-28292-x

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