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RAFT-Based Polymers for Click Reactions
The parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838018/ https://www.ncbi.nlm.nih.gov/pubmed/35160559 http://dx.doi.org/10.3390/polym14030570 |
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author | Chernikova, Elena V. Kudryavtsev, Yaroslav V. |
author_facet | Chernikova, Elena V. Kudryavtsev, Yaroslav V. |
author_sort | Chernikova, Elena V. |
collection | PubMed |
description | The parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functional polymers and their controlled conjugation with biomolecules, drugs, and inorganic surfaces. In this review, we discuss the results obtained with reversible addition–fragmentation chain transfer (RAFT) polymerization and different types of click reactions on low- and high-molar-mass reactants. Our classification of literature sources is based on the typical structure of macromolecules produced by the RAFT technique. The review addresses click reactions, immediate or preceded by a modification of another type, on the leaving and stabilizing groups inherited by a growing macromolecule from the chain transfer agent, as well as on the side groups coming from monomers entering the polymerization process. Architecture and self-assembling properties of the resulting polymers are briefly discussed with regard to their potential functional applications, which include drug delivery, protein recognition, anti-fouling and anti-corrosion coatings, the compatibilization of polymer blends, the modification of fillers to increase their dispersibility in polymer matrices, etc. |
format | Online Article Text |
id | pubmed-8838018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88380182022-02-13 RAFT-Based Polymers for Click Reactions Chernikova, Elena V. Kudryavtsev, Yaroslav V. Polymers (Basel) Review The parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functional polymers and their controlled conjugation with biomolecules, drugs, and inorganic surfaces. In this review, we discuss the results obtained with reversible addition–fragmentation chain transfer (RAFT) polymerization and different types of click reactions on low- and high-molar-mass reactants. Our classification of literature sources is based on the typical structure of macromolecules produced by the RAFT technique. The review addresses click reactions, immediate or preceded by a modification of another type, on the leaving and stabilizing groups inherited by a growing macromolecule from the chain transfer agent, as well as on the side groups coming from monomers entering the polymerization process. Architecture and self-assembling properties of the resulting polymers are briefly discussed with regard to their potential functional applications, which include drug delivery, protein recognition, anti-fouling and anti-corrosion coatings, the compatibilization of polymer blends, the modification of fillers to increase their dispersibility in polymer matrices, etc. MDPI 2022-01-31 /pmc/articles/PMC8838018/ /pubmed/35160559 http://dx.doi.org/10.3390/polym14030570 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chernikova, Elena V. Kudryavtsev, Yaroslav V. RAFT-Based Polymers for Click Reactions |
title | RAFT-Based Polymers for Click Reactions |
title_full | RAFT-Based Polymers for Click Reactions |
title_fullStr | RAFT-Based Polymers for Click Reactions |
title_full_unstemmed | RAFT-Based Polymers for Click Reactions |
title_short | RAFT-Based Polymers for Click Reactions |
title_sort | raft-based polymers for click reactions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838018/ https://www.ncbi.nlm.nih.gov/pubmed/35160559 http://dx.doi.org/10.3390/polym14030570 |
work_keys_str_mv | AT chernikovaelenav raftbasedpolymersforclickreactions AT kudryavtsevyaroslavv raftbasedpolymersforclickreactions |