Cargando…

Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis

Epileptogenesis is the gradual dynamic process that progressively led to epilepsy, going through the latent stage to the chronic stage. During epileptogenesis, how the abnormal discharges make theta rhythm loss in the deep brain remains not clear. In this paper, a loss of theta rhythm was estimated...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Xiaoxuan, Wang, Youhua, Belkacem, Abdelkader Nasreddine, Cao, Yingxin, Cheng, Hao, Zhao, Xiaohu, Chen, Shenghua, Chen, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838088/
https://www.ncbi.nlm.nih.gov/pubmed/35161860
http://dx.doi.org/10.3390/s22031114
_version_ 1784650039618961408
author Fu, Xiaoxuan
Wang, Youhua
Belkacem, Abdelkader Nasreddine
Cao, Yingxin
Cheng, Hao
Zhao, Xiaohu
Chen, Shenghua
Chen, Chao
author_facet Fu, Xiaoxuan
Wang, Youhua
Belkacem, Abdelkader Nasreddine
Cao, Yingxin
Cheng, Hao
Zhao, Xiaohu
Chen, Shenghua
Chen, Chao
author_sort Fu, Xiaoxuan
collection PubMed
description Epileptogenesis is the gradual dynamic process that progressively led to epilepsy, going through the latent stage to the chronic stage. During epileptogenesis, how the abnormal discharges make theta rhythm loss in the deep brain remains not clear. In this paper, a loss of theta rhythm was estimated based on time–frequency power using the longitudinal electroencephalography (EEG), recorded by deep brain electrodes (e.g., the intracortical microelectrodes such as stereo-EEG electrodes) with monitored epileptic spikes in a rat from the first region in the hippocampal circuit. Deep-brain EEG was collected from the period between adjacent sporadic interictal spikes (lasting 3.56 s—35.38 s) to the recovery period without spikes by videos while the rats were performing exploration. We found that loss of theta rhythm became more serious during the period between adjacent interictal spikes than during the recovery period without spike, and during epileptogenesis, more loss was observed at the acute stage than the chronic stage. We concluded that the emergence of the interictal spike was the direct cause of loss of theta rhythm, and the inhibitory effect of the interictal spike on ongoing theta rhythm was persistent as well as time dependent during epileptogenesis. With the help of the intracortical microelectrodes, this study provides a temporary proof of interictal spikes to produce ongoing theta rhythm loss, suggesting that the interictal spikes could correlate with the epileptogenesis process, display a time-dependent feature, and might be a potential biomarker to evaluate the deficits in theta-related memory in the brain.
format Online
Article
Text
id pubmed-8838088
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88380882022-02-13 Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis Fu, Xiaoxuan Wang, Youhua Belkacem, Abdelkader Nasreddine Cao, Yingxin Cheng, Hao Zhao, Xiaohu Chen, Shenghua Chen, Chao Sensors (Basel) Communication Epileptogenesis is the gradual dynamic process that progressively led to epilepsy, going through the latent stage to the chronic stage. During epileptogenesis, how the abnormal discharges make theta rhythm loss in the deep brain remains not clear. In this paper, a loss of theta rhythm was estimated based on time–frequency power using the longitudinal electroencephalography (EEG), recorded by deep brain electrodes (e.g., the intracortical microelectrodes such as stereo-EEG electrodes) with monitored epileptic spikes in a rat from the first region in the hippocampal circuit. Deep-brain EEG was collected from the period between adjacent sporadic interictal spikes (lasting 3.56 s—35.38 s) to the recovery period without spikes by videos while the rats were performing exploration. We found that loss of theta rhythm became more serious during the period between adjacent interictal spikes than during the recovery period without spike, and during epileptogenesis, more loss was observed at the acute stage than the chronic stage. We concluded that the emergence of the interictal spike was the direct cause of loss of theta rhythm, and the inhibitory effect of the interictal spike on ongoing theta rhythm was persistent as well as time dependent during epileptogenesis. With the help of the intracortical microelectrodes, this study provides a temporary proof of interictal spikes to produce ongoing theta rhythm loss, suggesting that the interictal spikes could correlate with the epileptogenesis process, display a time-dependent feature, and might be a potential biomarker to evaluate the deficits in theta-related memory in the brain. MDPI 2022-02-01 /pmc/articles/PMC8838088/ /pubmed/35161860 http://dx.doi.org/10.3390/s22031114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Fu, Xiaoxuan
Wang, Youhua
Belkacem, Abdelkader Nasreddine
Cao, Yingxin
Cheng, Hao
Zhao, Xiaohu
Chen, Shenghua
Chen, Chao
Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis
title Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis
title_full Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis
title_fullStr Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis
title_full_unstemmed Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis
title_short Interictal Spike and Loss of Hippocampal Theta Rhythm Recorded by Deep Brain Electrodes during Epileptogenesis
title_sort interictal spike and loss of hippocampal theta rhythm recorded by deep brain electrodes during epileptogenesis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838088/
https://www.ncbi.nlm.nih.gov/pubmed/35161860
http://dx.doi.org/10.3390/s22031114
work_keys_str_mv AT fuxiaoxuan interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT wangyouhua interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT belkacemabdelkadernasreddine interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT caoyingxin interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT chenghao interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT zhaoxiaohu interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT chenshenghua interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis
AT chenchao interictalspikeandlossofhippocampalthetarhythmrecordedbydeepbrainelectrodesduringepileptogenesis